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Gene Profiling of Aortic Valve Interstitial Cells under Elevated Pressure Conditions : Modulation of Inflammatory Gene Networks
المؤلفون المشاركون
Muir, William M.
Pregonero Gamez, Carol A.
Warnock, James N.
Tang, Juliet
Koback, Daniel
Burgess, Shane C.
Nanduri, Bindu
المصدر
International Journal of Inflammation
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-08-18
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The study aimed to identify mechanosensitive pathways and gene networks that are stimulated by elevated cyclic pressure in aortic valve interstitial cells (VICs) and lead to detrimental tissue remodeling and/or pathogenesis.
Porcine aortic valve leaflets were exposed to cyclic pressures of 80 or 120 mmHg, corresponding to diastolic transvalvular pressure in normal and hypertensive conditions, respectively.
Linear, two-cycle amplification of total RNA, followed by microarray was performed for transcriptome analysis (with qRT-PCR validation).
A combination of systems biology modeling and pathway analysis identified novel genes and molecular mechanisms underlying the biological response of VICs to elevated pressure.
56 gene transcripts related to inflammatory response mechanisms were differentially expressed.
TNF-α, IL-1α, and IL-1β were key cytokines identified from the gene network model.
Also of interest was the discovery that pentraxin 3 (PTX3) was significantly upregulated under elevated pressure conditions (41-fold change).
In conclusion, a gene network model showing differentially expressed inflammatory genes and their interactions in VICs exposed to elevated pressure has been developed.
This system overview has detected key molecules that could be targeted for pharmacotherapy of aortic stenosis in hypertensive patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Warnock, James N.& Nanduri, Bindu& Pregonero Gamez, Carol A.& Tang, Juliet& Koback, Daniel& Muir, William M.…[et al.]. 2011. Gene Profiling of Aortic Valve Interstitial Cells under Elevated Pressure Conditions : Modulation of Inflammatory Gene Networks. International Journal of Inflammation،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-452038
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Warnock, James N.…[et al.]. Gene Profiling of Aortic Valve Interstitial Cells under Elevated Pressure Conditions : Modulation of Inflammatory Gene Networks. International Journal of Inflammation No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-452038
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Warnock, James N.& Nanduri, Bindu& Pregonero Gamez, Carol A.& Tang, Juliet& Koback, Daniel& Muir, William M.…[et al.]. Gene Profiling of Aortic Valve Interstitial Cells under Elevated Pressure Conditions : Modulation of Inflammatory Gene Networks. International Journal of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-452038
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-452038
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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