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NOD2 Polymorphisms and Their Impact on Haematopoietic Stem Cell Transplant Outcome
المؤلفون المشاركون
Shaw, Bronwen E.
Madrigal, J. Alejandro
Marsh, Steven G. E.
Mayor, Neema P.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-18
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Haematopoietic stem cell transplantation (HSCT) is a valuable tool in the treatment of many haematological disorders.
Advances in understanding HLA matching have improved prognoses.
However, many recipients of well-matched HSCT develop posttransplant complications, and survival is far from absolute.
The pursuit of novel genetic factors that may impact on HSCT outcome has resulted in the publication of many articles on a multitude of genes.
Three NOD2 polymorphisms, identified as disease-associated variants in Crohn’s disease, have recently been suggested as important candidate gene markers in the outcome of HSCT.
It was originally postulated that as the clinical manifestation of inflammatory responses characteristic of several post-transplant complications was of notable similarity to those seen in Crohn’s disease, it was possible that they shared a common cause.
Since the publication of this first paper, numerous studies have attempted to replicate the results in different transplant settings.
The data has varied considerably between studies, and as yet no consensus on the impact of NOD2 SNPs on HSCT outcome has been achieved.
Here, we will review the existing literature, summarise current theories as to why the data differs, and suggest possible mechanisms by which the SNPs affect HSCT outcome.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mayor, Neema P.& Shaw, Bronwen E.& Madrigal, J. Alejandro& Marsh, Steven G. E.. 2012. NOD2 Polymorphisms and Their Impact on Haematopoietic Stem Cell Transplant Outcome. Bone Marrow Research،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-452314
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mayor, Neema P.…[et al.]. NOD2 Polymorphisms and Their Impact on Haematopoietic Stem Cell Transplant Outcome. Bone Marrow Research No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-452314
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mayor, Neema P.& Shaw, Bronwen E.& Madrigal, J. Alejandro& Marsh, Steven G. E.. NOD2 Polymorphisms and Their Impact on Haematopoietic Stem Cell Transplant Outcome. Bone Marrow Research. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-452314
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-452314
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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