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NOD2 Polymorphisms and Their Impact on Haematopoietic Stem Cell Transplant Outcome
Joint Authors
Shaw, Bronwen E.
Madrigal, J. Alejandro
Marsh, Steven G. E.
Mayor, Neema P.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Haematopoietic stem cell transplantation (HSCT) is a valuable tool in the treatment of many haematological disorders.
Advances in understanding HLA matching have improved prognoses.
However, many recipients of well-matched HSCT develop posttransplant complications, and survival is far from absolute.
The pursuit of novel genetic factors that may impact on HSCT outcome has resulted in the publication of many articles on a multitude of genes.
Three NOD2 polymorphisms, identified as disease-associated variants in Crohn’s disease, have recently been suggested as important candidate gene markers in the outcome of HSCT.
It was originally postulated that as the clinical manifestation of inflammatory responses characteristic of several post-transplant complications was of notable similarity to those seen in Crohn’s disease, it was possible that they shared a common cause.
Since the publication of this first paper, numerous studies have attempted to replicate the results in different transplant settings.
The data has varied considerably between studies, and as yet no consensus on the impact of NOD2 SNPs on HSCT outcome has been achieved.
Here, we will review the existing literature, summarise current theories as to why the data differs, and suggest possible mechanisms by which the SNPs affect HSCT outcome.
American Psychological Association (APA)
Mayor, Neema P.& Shaw, Bronwen E.& Madrigal, J. Alejandro& Marsh, Steven G. E.. 2012. NOD2 Polymorphisms and Their Impact on Haematopoietic Stem Cell Transplant Outcome. Bone Marrow Research،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-452314
Modern Language Association (MLA)
Mayor, Neema P.…[et al.]. NOD2 Polymorphisms and Their Impact on Haematopoietic Stem Cell Transplant Outcome. Bone Marrow Research No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-452314
American Medical Association (AMA)
Mayor, Neema P.& Shaw, Bronwen E.& Madrigal, J. Alejandro& Marsh, Steven G. E.. NOD2 Polymorphisms and Their Impact on Haematopoietic Stem Cell Transplant Outcome. Bone Marrow Research. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-452314
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452314