Anti-Diabetic Activities of Jiaotaiwan in dbdb Mice by Augmentation of AMPK Protein Activity and Upregulation of GLUT4 Expression
المؤلفون المشاركون
Li, Hui-Jiao
Lu, Xiong
Hu, Na
Lin, Min
Zhang, Yong-Yu
Zhong, Xiao-Yu
Yuan, Lin
Huang, Cheng
Mao, Quan-Ming
Tang, Peng
Sun, Yin-Qiang
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-29
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Jiaotaiwan (JTW), which is composed of Coptis chinensis (CC) and cinnamon (CIN), is one of the most well-known traditional Chinese medicines.
In this study, we investigated the antidiabetic effects and mechanism of JTW in db/db mice.
Results showed that JTW significantly decreased the level of fasting blood glucose and improved glucose and insulin tolerance better than CC or CIN alone.
JTW also effectively protected the pancreatic islet shape, augmented the activation of AMP-activated protein kinase (AMPK) in the liver, and increased the expression of glucose transporter 4 (GLUT4) protein in skeletal muscle and white fat.
AMPK and GLUT4 contributed to glucose metabolism regulation and had an essential function in the development of diabetes mellitus (DM).
Therefore, the mechanisms of JTW may be related to suppressing gluconeogenesis by activating AMPK in the liver and affecting glucose uptake in surrounding tissues through the upregulation of GLUT4 protein expression.
These findings provided a new insight into the antidiabetic clinical applications of JTW and demonstrated the potential of JTW as a new drug candidate for DM treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hu, Na& Yuan, Lin& Li, Hui-Jiao& Huang, Cheng& Mao, Quan-Ming& Zhang, Yong-Yu…[et al.]. 2013. Anti-Diabetic Activities of Jiaotaiwan in dbdb Mice by Augmentation of AMPK Protein Activity and Upregulation of GLUT4 Expression. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-452356
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hu, Na…[et al.]. Anti-Diabetic Activities of Jiaotaiwan in dbdb Mice by Augmentation of AMPK Protein Activity and Upregulation of GLUT4 Expression. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-452356
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hu, Na& Yuan, Lin& Li, Hui-Jiao& Huang, Cheng& Mao, Quan-Ming& Zhang, Yong-Yu…[et al.]. Anti-Diabetic Activities of Jiaotaiwan in dbdb Mice by Augmentation of AMPK Protein Activity and Upregulation of GLUT4 Expression. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-452356
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-452356
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر