Anti-Diabetic Activities of Jiaotaiwan in dbdb Mice by Augmentation of AMPK Protein Activity and Upregulation of GLUT4 Expression
Joint Authors
Li, Hui-Jiao
Lu, Xiong
Hu, Na
Lin, Min
Zhang, Yong-Yu
Zhong, Xiao-Yu
Yuan, Lin
Huang, Cheng
Mao, Quan-Ming
Tang, Peng
Sun, Yin-Qiang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Jiaotaiwan (JTW), which is composed of Coptis chinensis (CC) and cinnamon (CIN), is one of the most well-known traditional Chinese medicines.
In this study, we investigated the antidiabetic effects and mechanism of JTW in db/db mice.
Results showed that JTW significantly decreased the level of fasting blood glucose and improved glucose and insulin tolerance better than CC or CIN alone.
JTW also effectively protected the pancreatic islet shape, augmented the activation of AMP-activated protein kinase (AMPK) in the liver, and increased the expression of glucose transporter 4 (GLUT4) protein in skeletal muscle and white fat.
AMPK and GLUT4 contributed to glucose metabolism regulation and had an essential function in the development of diabetes mellitus (DM).
Therefore, the mechanisms of JTW may be related to suppressing gluconeogenesis by activating AMPK in the liver and affecting glucose uptake in surrounding tissues through the upregulation of GLUT4 protein expression.
These findings provided a new insight into the antidiabetic clinical applications of JTW and demonstrated the potential of JTW as a new drug candidate for DM treatment.
American Psychological Association (APA)
Hu, Na& Yuan, Lin& Li, Hui-Jiao& Huang, Cheng& Mao, Quan-Ming& Zhang, Yong-Yu…[et al.]. 2013. Anti-Diabetic Activities of Jiaotaiwan in dbdb Mice by Augmentation of AMPK Protein Activity and Upregulation of GLUT4 Expression. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-452356
Modern Language Association (MLA)
Hu, Na…[et al.]. Anti-Diabetic Activities of Jiaotaiwan in dbdb Mice by Augmentation of AMPK Protein Activity and Upregulation of GLUT4 Expression. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-452356
American Medical Association (AMA)
Hu, Na& Yuan, Lin& Li, Hui-Jiao& Huang, Cheng& Mao, Quan-Ming& Zhang, Yong-Yu…[et al.]. Anti-Diabetic Activities of Jiaotaiwan in dbdb Mice by Augmentation of AMPK Protein Activity and Upregulation of GLUT4 Expression. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-452356
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452356