Unexpected Lack of Deleterious Effects of Uranium on Physiological Systems following a Chronic Oral Intake in Adult Rat
المؤلفون المشاركون
Manens, Line
Grison, Stéphane
Kern, Yseult
Gueguen, Yann
Aigueperse, Jocelyne
Paulard, Anaïs
Rouas, Caroline
Monin, Audrey
Loyen, Jeanne
Delissen, Olivia
Lestaevel, Philippe
Dublineau, Isabelle
Bertho, Jean-Marc
Gourmelon, Patrick
Souidi, Maâmar
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-24، 24ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-12
دولة النشر
مصر
عدد الصفحات
24
التخصصات الرئيسية
الملخص EN
Uranium level in drinking water is usually in the range of microgram-per-liter, but this value may be as much as 100 to 1000 times higher in some areas, which may raise question about the health consequences for human populations living in these areas.
Our purpose was to improve knowledge of chemical effects of uranium following chronic ingestion.
Experiments were performed on rats contaminated for 9 months via drinking water containing depleted uranium (0.2, 2, 5, 10, 20, 40, or 120 mg/L).
Blood biochemical and hematological indicators were measured and several different types of investigations (molecular, functional, and structural) were conducted in organs (intestine, liver, kidneys, hematopoietic cells, and brain).
The specific sensitivity of the organs to uranium was deduced from nondeleterious biological effects, with the following thresholds (in mg/L): 0.2 for brain, >2 for liver, >10 for kidneys, and >20 for intestine, indicating a NOAEL (No-Observed-Adverse-Effect Level) threshold for uranium superior to 120 m g/L.
Based on the chemical uranium toxicity, the tolerable daily intake calculation yields a guideline value for humans of 1350 μg/L.
This value was higher than the WHO value of 30 μg/L, indicating that this WHO guideline for uranium content in drinking water is very protective and might be reconsidered.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dublineau, Isabelle& Souidi, Maâmar& Gueguen, Yann& Lestaevel, Philippe& Bertho, Jean-Marc& Manens, Line…[et al.]. 2014. Unexpected Lack of Deleterious Effects of Uranium on Physiological Systems following a Chronic Oral Intake in Adult Rat. BioMed Research International،Vol. 2014, no. 2014, pp.1-24.
https://search.emarefa.net/detail/BIM-452471
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dublineau, Isabelle…[et al.]. Unexpected Lack of Deleterious Effects of Uranium on Physiological Systems following a Chronic Oral Intake in Adult Rat. BioMed Research International No. 2014 (2014), pp.1-24.
https://search.emarefa.net/detail/BIM-452471
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dublineau, Isabelle& Souidi, Maâmar& Gueguen, Yann& Lestaevel, Philippe& Bertho, Jean-Marc& Manens, Line…[et al.]. Unexpected Lack of Deleterious Effects of Uranium on Physiological Systems following a Chronic Oral Intake in Adult Rat. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-24.
https://search.emarefa.net/detail/BIM-452471
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-452471
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر