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Unexpected Lack of Deleterious Effects of Uranium on Physiological Systems following a Chronic Oral Intake in Adult Rat
Joint Authors
Manens, Line
Grison, Stéphane
Kern, Yseult
Gueguen, Yann
Aigueperse, Jocelyne
Paulard, Anaïs
Rouas, Caroline
Monin, Audrey
Loyen, Jeanne
Delissen, Olivia
Lestaevel, Philippe
Dublineau, Isabelle
Bertho, Jean-Marc
Gourmelon, Patrick
Souidi, Maâmar
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-24, 24 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-12
Country of Publication
Egypt
No. of Pages
24
Main Subjects
Abstract EN
Uranium level in drinking water is usually in the range of microgram-per-liter, but this value may be as much as 100 to 1000 times higher in some areas, which may raise question about the health consequences for human populations living in these areas.
Our purpose was to improve knowledge of chemical effects of uranium following chronic ingestion.
Experiments were performed on rats contaminated for 9 months via drinking water containing depleted uranium (0.2, 2, 5, 10, 20, 40, or 120 mg/L).
Blood biochemical and hematological indicators were measured and several different types of investigations (molecular, functional, and structural) were conducted in organs (intestine, liver, kidneys, hematopoietic cells, and brain).
The specific sensitivity of the organs to uranium was deduced from nondeleterious biological effects, with the following thresholds (in mg/L): 0.2 for brain, >2 for liver, >10 for kidneys, and >20 for intestine, indicating a NOAEL (No-Observed-Adverse-Effect Level) threshold for uranium superior to 120 m g/L.
Based on the chemical uranium toxicity, the tolerable daily intake calculation yields a guideline value for humans of 1350 μg/L.
This value was higher than the WHO value of 30 μg/L, indicating that this WHO guideline for uranium content in drinking water is very protective and might be reconsidered.
American Psychological Association (APA)
Dublineau, Isabelle& Souidi, Maâmar& Gueguen, Yann& Lestaevel, Philippe& Bertho, Jean-Marc& Manens, Line…[et al.]. 2014. Unexpected Lack of Deleterious Effects of Uranium on Physiological Systems following a Chronic Oral Intake in Adult Rat. BioMed Research International،Vol. 2014, no. 2014, pp.1-24.
https://search.emarefa.net/detail/BIM-452471
Modern Language Association (MLA)
Dublineau, Isabelle…[et al.]. Unexpected Lack of Deleterious Effects of Uranium on Physiological Systems following a Chronic Oral Intake in Adult Rat. BioMed Research International No. 2014 (2014), pp.1-24.
https://search.emarefa.net/detail/BIM-452471
American Medical Association (AMA)
Dublineau, Isabelle& Souidi, Maâmar& Gueguen, Yann& Lestaevel, Philippe& Bertho, Jean-Marc& Manens, Line…[et al.]. Unexpected Lack of Deleterious Effects of Uranium on Physiological Systems following a Chronic Oral Intake in Adult Rat. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-24.
https://search.emarefa.net/detail/BIM-452471
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452471