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Glioprotective Effects of Ashwagandha Leaf Extract against Lead Induced Toxicity
المؤلفون المشاركون
Kaur, Gurcharan
Kumar, Praveen
Singh, Raghavendra
Nazmi, Arshed
Lakhanpal, Dinesh
Kataria, Hardeep
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-28
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Withania somnifera (Ashwagandha), also known as Indian Ginseng, is a well-known Indian medicinal plant due to its antioxidative, antistress, antigenotoxic, and immunomodulatory properties.
The present study was designed to assess and establish the cytoprotective potential of Ashwagandha leaf aqueous extract against lead induced toxicity.
Pretreatment of C6 cells with 0.1% Ashwagandha extract showed cytoprotection against 25 μM to 400 μM concentration of lead nitrate.
Further pretreatment with Ashwagandha extract to lead nitrate exposed cells (200 μM) resulted in normalization of glial fibrillary acidic protein (GFAP) expression as well as heat shock protein (HSP70), mortalin, and neural cell adhesion molecule (NCAM) expression.
Further, the cytoprotective efficacy of Ashwagandha extract was studied in vivo.
Administration of Ashwagandha extract provided significant protection to lead induced altered antioxidant defense that may significantly compromise normal cellular function.
Ashwagandha also provided a significant protection to lipid peroxidation (LPx) levels, catalase, and superoxide dismutase (SOD) but not reduced glutathione (GSH) contents in brain tissue as well as peripheral organs, liver and kidney, suggesting its ability to act as a free radical scavenger protecting cells against toxic insult.
These results, thus, suggest that Ashwagandha water extract may have the potential therapeutic implication against lead poisoning.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kumar, Praveen& Singh, Raghavendra& Nazmi, Arshed& Lakhanpal, Dinesh& Kataria, Hardeep& Kaur, Gurcharan. 2014. Glioprotective Effects of Ashwagandha Leaf Extract against Lead Induced Toxicity. BioMed Research International،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-452473
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kumar, Praveen…[et al.]. Glioprotective Effects of Ashwagandha Leaf Extract against Lead Induced Toxicity. BioMed Research International No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-452473
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kumar, Praveen& Singh, Raghavendra& Nazmi, Arshed& Lakhanpal, Dinesh& Kataria, Hardeep& Kaur, Gurcharan. Glioprotective Effects of Ashwagandha Leaf Extract against Lead Induced Toxicity. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-452473
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-452473
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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