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Glioprotective Effects of Ashwagandha Leaf Extract against Lead Induced Toxicity
Joint Authors
Kaur, Gurcharan
Kumar, Praveen
Singh, Raghavendra
Nazmi, Arshed
Lakhanpal, Dinesh
Kataria, Hardeep
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-28
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Withania somnifera (Ashwagandha), also known as Indian Ginseng, is a well-known Indian medicinal plant due to its antioxidative, antistress, antigenotoxic, and immunomodulatory properties.
The present study was designed to assess and establish the cytoprotective potential of Ashwagandha leaf aqueous extract against lead induced toxicity.
Pretreatment of C6 cells with 0.1% Ashwagandha extract showed cytoprotection against 25 μM to 400 μM concentration of lead nitrate.
Further pretreatment with Ashwagandha extract to lead nitrate exposed cells (200 μM) resulted in normalization of glial fibrillary acidic protein (GFAP) expression as well as heat shock protein (HSP70), mortalin, and neural cell adhesion molecule (NCAM) expression.
Further, the cytoprotective efficacy of Ashwagandha extract was studied in vivo.
Administration of Ashwagandha extract provided significant protection to lead induced altered antioxidant defense that may significantly compromise normal cellular function.
Ashwagandha also provided a significant protection to lipid peroxidation (LPx) levels, catalase, and superoxide dismutase (SOD) but not reduced glutathione (GSH) contents in brain tissue as well as peripheral organs, liver and kidney, suggesting its ability to act as a free radical scavenger protecting cells against toxic insult.
These results, thus, suggest that Ashwagandha water extract may have the potential therapeutic implication against lead poisoning.
American Psychological Association (APA)
Kumar, Praveen& Singh, Raghavendra& Nazmi, Arshed& Lakhanpal, Dinesh& Kataria, Hardeep& Kaur, Gurcharan. 2014. Glioprotective Effects of Ashwagandha Leaf Extract against Lead Induced Toxicity. BioMed Research International،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-452473
Modern Language Association (MLA)
Kumar, Praveen…[et al.]. Glioprotective Effects of Ashwagandha Leaf Extract against Lead Induced Toxicity. BioMed Research International No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-452473
American Medical Association (AMA)
Kumar, Praveen& Singh, Raghavendra& Nazmi, Arshed& Lakhanpal, Dinesh& Kataria, Hardeep& Kaur, Gurcharan. Glioprotective Effects of Ashwagandha Leaf Extract against Lead Induced Toxicity. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-452473
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452473