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Trunk Fat Negatively Influences Skeletal and Testicular Functions in Obese Men : Clinical Implications for the Aging Male
المؤلفون المشاركون
Bruzziches, Roberto
Migliaccio, Silvia
Donini, Lorenzo M.
Greco, Emanuela A.
Fornari, Rachele
Aversa, Antonio
Lenzi, Andrea
Francomano, Davide
المصدر
International Journal of Endocrinology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-20
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Osteocalcin (OSCA) seems to act as a negative regulator of energy metabolism and insulin sensitivity.
Evidence from male rodents suggests that OSCA may also regulate testosterone (T) synthesis.
Using a cross-sectional design, we evaluated OSCA, 25(OH) vitamin D, T, 17β-estradiol (E2), homeostasis model assessment of insulin resistance (HOMA-IR), and body composition in 86 obese (mean BMI = 34) male subjects (18–69 yr old).
Independently from BMI, an inverse relationship between trunk fat percentage and plasma T (r2=−0.26, P<0.01) and between HOMA-IR and OSCA levels (r2=−0.22, P<0.005) was found.
OSCA levels, as well as vitamin D, decreased significantly for higher BMI with significant differences above 35 (P<0.01).
A direct correlation between T and bone mineral density at lumbar (BMDL) and neck (BMDH) (P<0.001, r2=−0.20; P<0.001, r2=−0.24) was found, independently from age.
An inverse correlation between E2 levels, BMDL, and BMDH (P<0.001, r2=−0.20; P<0.001, r2=−0.19) was observed.
These data provide new evidences that a relationship between trunk fat mass, insulin sensitivity, OSCA and T synthesis occurs.
This new relationship with skeletal health has relevant implications for the aging male, suggesting OSCA as a novel marker of metabolic and gonadal health status.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Migliaccio, Silvia& Francomano, Davide& Bruzziches, Roberto& Greco, Emanuela A.& Fornari, Rachele& Donini, Lorenzo M.…[et al.]. 2013. Trunk Fat Negatively Influences Skeletal and Testicular Functions in Obese Men : Clinical Implications for the Aging Male. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-452529
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Migliaccio, Silvia…[et al.]. Trunk Fat Negatively Influences Skeletal and Testicular Functions in Obese Men : Clinical Implications for the Aging Male. International Journal of Endocrinology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-452529
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Migliaccio, Silvia& Francomano, Davide& Bruzziches, Roberto& Greco, Emanuela A.& Fornari, Rachele& Donini, Lorenzo M.…[et al.]. Trunk Fat Negatively Influences Skeletal and Testicular Functions in Obese Men : Clinical Implications for the Aging Male. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-452529
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-452529
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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