Trunk Fat Negatively Influences Skeletal and Testicular Functions in Obese Men : Clinical Implications for the Aging Male
Joint Authors
Bruzziches, Roberto
Migliaccio, Silvia
Donini, Lorenzo M.
Greco, Emanuela A.
Fornari, Rachele
Aversa, Antonio
Lenzi, Andrea
Francomano, Davide
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Osteocalcin (OSCA) seems to act as a negative regulator of energy metabolism and insulin sensitivity.
Evidence from male rodents suggests that OSCA may also regulate testosterone (T) synthesis.
Using a cross-sectional design, we evaluated OSCA, 25(OH) vitamin D, T, 17β-estradiol (E2), homeostasis model assessment of insulin resistance (HOMA-IR), and body composition in 86 obese (mean BMI = 34) male subjects (18–69 yr old).
Independently from BMI, an inverse relationship between trunk fat percentage and plasma T (r2=−0.26, P<0.01) and between HOMA-IR and OSCA levels (r2=−0.22, P<0.005) was found.
OSCA levels, as well as vitamin D, decreased significantly for higher BMI with significant differences above 35 (P<0.01).
A direct correlation between T and bone mineral density at lumbar (BMDL) and neck (BMDH) (P<0.001, r2=−0.20; P<0.001, r2=−0.24) was found, independently from age.
An inverse correlation between E2 levels, BMDL, and BMDH (P<0.001, r2=−0.20; P<0.001, r2=−0.19) was observed.
These data provide new evidences that a relationship between trunk fat mass, insulin sensitivity, OSCA and T synthesis occurs.
This new relationship with skeletal health has relevant implications for the aging male, suggesting OSCA as a novel marker of metabolic and gonadal health status.
American Psychological Association (APA)
Migliaccio, Silvia& Francomano, Davide& Bruzziches, Roberto& Greco, Emanuela A.& Fornari, Rachele& Donini, Lorenzo M.…[et al.]. 2013. Trunk Fat Negatively Influences Skeletal and Testicular Functions in Obese Men : Clinical Implications for the Aging Male. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-452529
Modern Language Association (MLA)
Migliaccio, Silvia…[et al.]. Trunk Fat Negatively Influences Skeletal and Testicular Functions in Obese Men : Clinical Implications for the Aging Male. International Journal of Endocrinology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-452529
American Medical Association (AMA)
Migliaccio, Silvia& Francomano, Davide& Bruzziches, Roberto& Greco, Emanuela A.& Fornari, Rachele& Donini, Lorenzo M.…[et al.]. Trunk Fat Negatively Influences Skeletal and Testicular Functions in Obese Men : Clinical Implications for the Aging Male. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-452529
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452529