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DNA Damage in Rheumatoid Arthritis : An Age-Dependent Increase in the Lipid Peroxidation-Derived DNA Adduct, Heptanone-Etheno-2′-Deoxycytidine
المؤلفون المشاركون
Toyofuku, Toshihiko
Matsuda, Tomonari
Hamasaki, Toshimitsu
Kumanogoh, Atsushi
Ogata, Atsushi
Ogawa, Masako
Tanaka, Toshio
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-07
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
To evaluate what types of DNA damages are detected in rheumatoid arthritis (RA).
Methods.
The DNA adducts such as 8-oxo-hydroxy-7,8-dihydro-2′-deoxyguanosine (8-oxo-dG), 1,N6-etheno-2′-deoxyadenosine (εdA), and heptanone-etheno-2′-deoxycytidine (HεdC) in genomic DNAs, derived from whole blood cells from 46 RA patients and 31 healthy controls, were analyzed by high-performance liquid chromatography tandem mass spectrometry, and their levels in RA patients and controls were compared.
In addition, correlation between DNA adducts and clinical parameters of RA was analyzed.
Results.
Compared with controls, the levels of HεdC in RA were significantly higher (P<0.0001) and age dependent (r = 0.43, P < 0.01), while there was no significant difference in 8-oxo-dG and εdA accumulation between RA patients and controls.
HεdC levels correlated well with the number of swollen joints (r = 0.57, P < 0.0001) and weakly with the number of tender joints (r = 0.26, P = 0.08) of RA patients, while they did not show a significant association with serological markers such as C-reactive protein and matrix metalloproteinase 3.
Conclusion.
These findings indicate that HεdC may have some influence on the development of RA and/or its complications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ogawa, Masako& Matsuda, Tomonari& Ogata, Atsushi& Hamasaki, Toshimitsu& Kumanogoh, Atsushi& Toyofuku, Toshihiko…[et al.]. 2013. DNA Damage in Rheumatoid Arthritis : An Age-Dependent Increase in the Lipid Peroxidation-Derived DNA Adduct, Heptanone-Etheno-2′-Deoxycytidine. Autoimmune Diseases،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-452598
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ogawa, Masako…[et al.]. DNA Damage in Rheumatoid Arthritis : An Age-Dependent Increase in the Lipid Peroxidation-Derived DNA Adduct, Heptanone-Etheno-2′-Deoxycytidine. Autoimmune Diseases No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-452598
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ogawa, Masako& Matsuda, Tomonari& Ogata, Atsushi& Hamasaki, Toshimitsu& Kumanogoh, Atsushi& Toyofuku, Toshihiko…[et al.]. DNA Damage in Rheumatoid Arthritis : An Age-Dependent Increase in the Lipid Peroxidation-Derived DNA Adduct, Heptanone-Etheno-2′-Deoxycytidine. Autoimmune Diseases. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-452598
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-452598
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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