DNA Damage in Rheumatoid Arthritis : An Age-Dependent Increase in the Lipid Peroxidation-Derived DNA Adduct, Heptanone-Etheno-2′-Deoxycytidine
Joint Authors
Toyofuku, Toshihiko
Matsuda, Tomonari
Hamasaki, Toshimitsu
Kumanogoh, Atsushi
Ogata, Atsushi
Ogawa, Masako
Tanaka, Toshio
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To evaluate what types of DNA damages are detected in rheumatoid arthritis (RA).
Methods.
The DNA adducts such as 8-oxo-hydroxy-7,8-dihydro-2′-deoxyguanosine (8-oxo-dG), 1,N6-etheno-2′-deoxyadenosine (εdA), and heptanone-etheno-2′-deoxycytidine (HεdC) in genomic DNAs, derived from whole blood cells from 46 RA patients and 31 healthy controls, were analyzed by high-performance liquid chromatography tandem mass spectrometry, and their levels in RA patients and controls were compared.
In addition, correlation between DNA adducts and clinical parameters of RA was analyzed.
Results.
Compared with controls, the levels of HεdC in RA were significantly higher (P<0.0001) and age dependent (r = 0.43, P < 0.01), while there was no significant difference in 8-oxo-dG and εdA accumulation between RA patients and controls.
HεdC levels correlated well with the number of swollen joints (r = 0.57, P < 0.0001) and weakly with the number of tender joints (r = 0.26, P = 0.08) of RA patients, while they did not show a significant association with serological markers such as C-reactive protein and matrix metalloproteinase 3.
Conclusion.
These findings indicate that HεdC may have some influence on the development of RA and/or its complications.
American Psychological Association (APA)
Ogawa, Masako& Matsuda, Tomonari& Ogata, Atsushi& Hamasaki, Toshimitsu& Kumanogoh, Atsushi& Toyofuku, Toshihiko…[et al.]. 2013. DNA Damage in Rheumatoid Arthritis : An Age-Dependent Increase in the Lipid Peroxidation-Derived DNA Adduct, Heptanone-Etheno-2′-Deoxycytidine. Autoimmune Diseases،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-452598
Modern Language Association (MLA)
Ogawa, Masako…[et al.]. DNA Damage in Rheumatoid Arthritis : An Age-Dependent Increase in the Lipid Peroxidation-Derived DNA Adduct, Heptanone-Etheno-2′-Deoxycytidine. Autoimmune Diseases No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-452598
American Medical Association (AMA)
Ogawa, Masako& Matsuda, Tomonari& Ogata, Atsushi& Hamasaki, Toshimitsu& Kumanogoh, Atsushi& Toyofuku, Toshihiko…[et al.]. DNA Damage in Rheumatoid Arthritis : An Age-Dependent Increase in the Lipid Peroxidation-Derived DNA Adduct, Heptanone-Etheno-2′-Deoxycytidine. Autoimmune Diseases. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-452598
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452598