Ginsenoside-Rb1 Induces ARPE-19 Proliferation and Reduces VEGF Release

المؤلفون المشاركون

Betts, Brandi S.
Tsin, Andrew T. C.
Yendluri, Bharat B.
Grigsby, Jeffery
Parvathaneni, Kalpana

المصدر

ISRN Ophthalmology

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-6، 6ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-01-04

دولة النشر

مصر

عدد الصفحات

6

التخصصات الرئيسية

الطب البشري

الملخص EN

Rb1, a ginsenoside from ginseng root extract, possesses antiangiogenic effects, but its role on ocular cells has not been studied.

We hypothesize that Rb1 inhibits the production of the angiogenic cytokine VEGF from ARPE-19 cells, leading to a significant reduction in the proliferation of ocular vasculatures.

Data from our experiments show that Rb1 induced an increase in the number of ARPE cells in culture, while VEGF release (pg/10,000 viable cells) was significantly reduced.

Treatment with VEGF and cotreatment with Rb1 and VEGF showed that this Rb1-induced cell proliferation was mediated by VEGF.

Because VEGF from RPE plays a major role in promoting angiogenesis in ocular vasculatures.

Our finding that Rb1 inhibits the release of VEGF from RPE cells suggests that Rb1 has a significant role in the eye to protect against angiogenic diseases such as age-related macular degeneration.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Betts, Brandi S.& Parvathaneni, Kalpana& Yendluri, Bharat B.& Grigsby, Jeffery& Tsin, Andrew T. C.. 2012. Ginsenoside-Rb1 Induces ARPE-19 Proliferation and Reduces VEGF Release. ISRN Ophthalmology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-452677

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Betts, Brandi S.…[et al.]. Ginsenoside-Rb1 Induces ARPE-19 Proliferation and Reduces VEGF Release. ISRN Ophthalmology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-452677

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Betts, Brandi S.& Parvathaneni, Kalpana& Yendluri, Bharat B.& Grigsby, Jeffery& Tsin, Andrew T. C.. Ginsenoside-Rb1 Induces ARPE-19 Proliferation and Reduces VEGF Release. ISRN Ophthalmology. 2012. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-452677

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-452677