Ginsenoside-Rb1 Induces ARPE-19 Proliferation and Reduces VEGF Release
Joint Authors
Betts, Brandi S.
Tsin, Andrew T. C.
Yendluri, Bharat B.
Grigsby, Jeffery
Parvathaneni, Kalpana
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Rb1, a ginsenoside from ginseng root extract, possesses antiangiogenic effects, but its role on ocular cells has not been studied.
We hypothesize that Rb1 inhibits the production of the angiogenic cytokine VEGF from ARPE-19 cells, leading to a significant reduction in the proliferation of ocular vasculatures.
Data from our experiments show that Rb1 induced an increase in the number of ARPE cells in culture, while VEGF release (pg/10,000 viable cells) was significantly reduced.
Treatment with VEGF and cotreatment with Rb1 and VEGF showed that this Rb1-induced cell proliferation was mediated by VEGF.
Because VEGF from RPE plays a major role in promoting angiogenesis in ocular vasculatures.
Our finding that Rb1 inhibits the release of VEGF from RPE cells suggests that Rb1 has a significant role in the eye to protect against angiogenic diseases such as age-related macular degeneration.
American Psychological Association (APA)
Betts, Brandi S.& Parvathaneni, Kalpana& Yendluri, Bharat B.& Grigsby, Jeffery& Tsin, Andrew T. C.. 2012. Ginsenoside-Rb1 Induces ARPE-19 Proliferation and Reduces VEGF Release. ISRN Ophthalmology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-452677
Modern Language Association (MLA)
Betts, Brandi S.…[et al.]. Ginsenoside-Rb1 Induces ARPE-19 Proliferation and Reduces VEGF Release. ISRN Ophthalmology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-452677
American Medical Association (AMA)
Betts, Brandi S.& Parvathaneni, Kalpana& Yendluri, Bharat B.& Grigsby, Jeffery& Tsin, Andrew T. C.. Ginsenoside-Rb1 Induces ARPE-19 Proliferation and Reduces VEGF Release. ISRN Ophthalmology. 2012. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-452677
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452677