Overexpression of FOXO3, MYD88, and GAPDH Identified by Suppression Subtractive Hybridization in Esophageal Cancer Is Associated with Autophagy
المؤلفون المشاركون
Sepehrizadeh, Zargham
Roshandel, Gholamreza
Mottaghi-Dastjerdi, Negar
Soltany-Rezaee-Rad, Mohammad
Setayesh, Neda
Ebrahimifard, Farzaneh
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-08
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
To find genes involved in tumorigenesis and the development of esophageal cancer, the suppression subtractive hybridization (SSH) method was used to identify genes that are overexpressed in esophageal cancer tissues compared to normal esophageal tissues.
In our SSH library, the forkhead box O3 (FOXO3), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and myeloid differentiation primary response 88 (MYD88) genes were the most highly upregulated genes, and they were selected for further studies because of their potential role in the induction of autophagy.
Upregulation of these genes was also observed in clinical samples using qRT-PCR.
In addition, coexpression analysis of the autophagy-related genes Beclin1, ATG12, Gabarapl, PIK3C3, and LC3 demonstrated a significant correlation between the differentially overexpressed genes and autophagy.
Autophagy is an important mechanism in tumorigenesis and the development of chemoresistance in cancer cells.
The upregulation of FOXO3, GAPDH, and MYD88 variants in esophageal cancer suggests a role for autophagy and provides new insight into the biology of esophageal cancer.
We propose that FOXO3, GAPDH, and MYD88 are novel targets for combating autophagy in esophageal cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Soltany-Rezaee-Rad, Mohammad& Mottaghi-Dastjerdi, Negar& Setayesh, Neda& Roshandel, Gholamreza& Ebrahimifard, Farzaneh& Sepehrizadeh, Zargham. 2014. Overexpression of FOXO3, MYD88, and GAPDH Identified by Suppression Subtractive Hybridization in Esophageal Cancer Is Associated with Autophagy. Gastroenterology Research and Practice،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-452736
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Soltany-Rezaee-Rad, Mohammad…[et al.]. Overexpression of FOXO3, MYD88, and GAPDH Identified by Suppression Subtractive Hybridization in Esophageal Cancer Is Associated with Autophagy. Gastroenterology Research and Practice No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-452736
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Soltany-Rezaee-Rad, Mohammad& Mottaghi-Dastjerdi, Negar& Setayesh, Neda& Roshandel, Gholamreza& Ebrahimifard, Farzaneh& Sepehrizadeh, Zargham. Overexpression of FOXO3, MYD88, and GAPDH Identified by Suppression Subtractive Hybridization in Esophageal Cancer Is Associated with Autophagy. Gastroenterology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-452736
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-452736
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر