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Overexpression of FOXO3, MYD88, and GAPDH Identified by Suppression Subtractive Hybridization in Esophageal Cancer Is Associated with Autophagy
Joint Authors
Sepehrizadeh, Zargham
Roshandel, Gholamreza
Mottaghi-Dastjerdi, Negar
Soltany-Rezaee-Rad, Mohammad
Setayesh, Neda
Ebrahimifard, Farzaneh
Source
Gastroenterology Research and Practice
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
To find genes involved in tumorigenesis and the development of esophageal cancer, the suppression subtractive hybridization (SSH) method was used to identify genes that are overexpressed in esophageal cancer tissues compared to normal esophageal tissues.
In our SSH library, the forkhead box O3 (FOXO3), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and myeloid differentiation primary response 88 (MYD88) genes were the most highly upregulated genes, and they were selected for further studies because of their potential role in the induction of autophagy.
Upregulation of these genes was also observed in clinical samples using qRT-PCR.
In addition, coexpression analysis of the autophagy-related genes Beclin1, ATG12, Gabarapl, PIK3C3, and LC3 demonstrated a significant correlation between the differentially overexpressed genes and autophagy.
Autophagy is an important mechanism in tumorigenesis and the development of chemoresistance in cancer cells.
The upregulation of FOXO3, GAPDH, and MYD88 variants in esophageal cancer suggests a role for autophagy and provides new insight into the biology of esophageal cancer.
We propose that FOXO3, GAPDH, and MYD88 are novel targets for combating autophagy in esophageal cancer.
American Psychological Association (APA)
Soltany-Rezaee-Rad, Mohammad& Mottaghi-Dastjerdi, Negar& Setayesh, Neda& Roshandel, Gholamreza& Ebrahimifard, Farzaneh& Sepehrizadeh, Zargham. 2014. Overexpression of FOXO3, MYD88, and GAPDH Identified by Suppression Subtractive Hybridization in Esophageal Cancer Is Associated with Autophagy. Gastroenterology Research and Practice،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-452736
Modern Language Association (MLA)
Soltany-Rezaee-Rad, Mohammad…[et al.]. Overexpression of FOXO3, MYD88, and GAPDH Identified by Suppression Subtractive Hybridization in Esophageal Cancer Is Associated with Autophagy. Gastroenterology Research and Practice No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-452736
American Medical Association (AMA)
Soltany-Rezaee-Rad, Mohammad& Mottaghi-Dastjerdi, Negar& Setayesh, Neda& Roshandel, Gholamreza& Ebrahimifard, Farzaneh& Sepehrizadeh, Zargham. Overexpression of FOXO3, MYD88, and GAPDH Identified by Suppression Subtractive Hybridization in Esophageal Cancer Is Associated with Autophagy. Gastroenterology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-452736
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452736