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Effects of Chlorophyll-Derived Efflux Pump Inhibitor Pheophorbide a and Pyropheophorbide a on Growth and Macrolide Antibiotic Resistance of Indicator and Anaerobic Swine Manure Bacteria
المؤلفون المشاركون
Whitehead, Terence R.
Cotta, Michael A.
Rasmussen, Mark A.
Kraatz, Mareike
Berhow, Mark A.
المصدر
International Journal of Antibiotics
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-11
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Natural plant compounds, such as the chlorophyll a catabolites pheophorbide a (php) and pyropheophorbide a (pyp), are potentially active in the gastrointestinal tracts and manure of livestock as antimicrobial resistance-modifying agents through inhibition of bacterial efflux pumps.
To investigate whether php, a known efflux pump inhibitor, and pyp influence bacterial resistance, we determined their long-term effects on the MICs of erythromycin for reference strains of clinically relevant indicator bacteria with macrolide or multidrug resistance efflux pumps.
Pyp reduced the final MIC endpoint for Staphylococcus (S.) aureus and Escherichia (E.) coli by up to 1536 and 1024 μg erythromycin mL−1 or 1.4- and 1.2-fold, respectively.
Estimation of growth parameters of S.
aureus revealed that pyp exerted an intrinsic inhibitory effect under anaerobic conditions and was synergistically active, thereby potentiating the effect of erythromycin and partially reversing high-level erythromycin resistance.
Anaerobe colony counts of total and erythromycin-resistant bacteria from stored swine manure samples tended to be lower in the presence of pyp.
Tylosin, php, and pyp were not detectable by HPLC in the manure or medium.
This is the first study showing that pyp affects growth and the level of sensitivity to erythromycin of S.
aureus, E.
coli, and anaerobic manure bacteria.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kraatz, Mareike& Whitehead, Terence R.& Cotta, Michael A.& Berhow, Mark A.& Rasmussen, Mark A.. 2014. Effects of Chlorophyll-Derived Efflux Pump Inhibitor Pheophorbide a and Pyropheophorbide a on Growth and Macrolide Antibiotic Resistance of Indicator and Anaerobic Swine Manure Bacteria. International Journal of Antibiotics،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-452740
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kraatz, Mareike…[et al.]. Effects of Chlorophyll-Derived Efflux Pump Inhibitor Pheophorbide a and Pyropheophorbide a on Growth and Macrolide Antibiotic Resistance of Indicator and Anaerobic Swine Manure Bacteria. International Journal of Antibiotics No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-452740
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kraatz, Mareike& Whitehead, Terence R.& Cotta, Michael A.& Berhow, Mark A.& Rasmussen, Mark A.. Effects of Chlorophyll-Derived Efflux Pump Inhibitor Pheophorbide a and Pyropheophorbide a on Growth and Macrolide Antibiotic Resistance of Indicator and Anaerobic Swine Manure Bacteria. International Journal of Antibiotics. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-452740
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-452740
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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