Beta-Glucan-Rich Extract from Pleurotus sajor-caju (Fr.) Singer Prevents Obesity and Oxidative Stress in C57BL6J Mice Fed on a High-Fat Diet
المؤلفون المشاركون
Abd Malek, Sri Nurestri
Kanagasabapathy, Gowri
Chua, Kek Heng
Abdulla, Mahmood Ameen
Kuppusamy, Umah Rani
Sabaratnam, Vikineswary
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-07
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Mushrooms have been used in folk medicine for thousands of years.
In this study, the effect of β-glucan-rich extract of P.
sajor-caju (GE) on lipid lowering and antioxidant potential was assessed in C57BL/6J mice fed on a high-fat diet.
Obesity was induced in C57BL/6J mice by feeding a high-fat diet.
The control groups in this study were ND (for normal diet) and HFD (for high-fat diet).
The treated groups were ND240 (for normal diet) (240 mg/kg b.w) and HFD60, HFD120, and HFD240 (for high-fat diet), where the mice were administrated with three dosages of GE (60, 120, and 240 mg GE/kg b.w).
Metformin (2 mg/kg b.w) served as positive control.
GE-treated groups showed significantly reduced body weight, serum lipid, and liver enzymes levels.
GE also attenuated protein carbonyl and lipid hydroperoxide levels by increasing the enzymic antioxidants (SOD, CAT, and GPx) activities in the mice.
GE-treated groups induced the expression of hormone sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) while downregulated the expression of peroxisome proliferator-activated receptor gamma (PPAR-γ), sterol regulatory binding protein-1c (SREBP-1c), and lipoprotein lipase (LPL).
Hence, GE prevented weight gain in the mice by inducing lipolysis and may be valuable in the formulation of adjuvant therapy for obesity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kanagasabapathy, Gowri& Abd Malek, Sri Nurestri& Abdulla, Mahmood Ameen& Chua, Kek Heng& Sabaratnam, Vikineswary& Kuppusamy, Umah Rani. 2013. Beta-Glucan-Rich Extract from Pleurotus sajor-caju (Fr.) Singer Prevents Obesity and Oxidative Stress in C57BL6J Mice Fed on a High-Fat Diet. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-452754
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kanagasabapathy, Gowri…[et al.]. Beta-Glucan-Rich Extract from Pleurotus sajor-caju (Fr.) Singer Prevents Obesity and Oxidative Stress in C57BL6J Mice Fed on a High-Fat Diet. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-452754
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kanagasabapathy, Gowri& Abd Malek, Sri Nurestri& Abdulla, Mahmood Ameen& Chua, Kek Heng& Sabaratnam, Vikineswary& Kuppusamy, Umah Rani. Beta-Glucan-Rich Extract from Pleurotus sajor-caju (Fr.) Singer Prevents Obesity and Oxidative Stress in C57BL6J Mice Fed on a High-Fat Diet. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-452754
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-452754
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر