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Beta-Glucan-Rich Extract from Pleurotus sajor-caju (Fr.) Singer Prevents Obesity and Oxidative Stress in C57BL6J Mice Fed on a High-Fat Diet
Joint Authors
Abd Malek, Sri Nurestri
Kanagasabapathy, Gowri
Chua, Kek Heng
Abdulla, Mahmood Ameen
Kuppusamy, Umah Rani
Sabaratnam, Vikineswary
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Mushrooms have been used in folk medicine for thousands of years.
In this study, the effect of β-glucan-rich extract of P.
sajor-caju (GE) on lipid lowering and antioxidant potential was assessed in C57BL/6J mice fed on a high-fat diet.
Obesity was induced in C57BL/6J mice by feeding a high-fat diet.
The control groups in this study were ND (for normal diet) and HFD (for high-fat diet).
The treated groups were ND240 (for normal diet) (240 mg/kg b.w) and HFD60, HFD120, and HFD240 (for high-fat diet), where the mice were administrated with three dosages of GE (60, 120, and 240 mg GE/kg b.w).
Metformin (2 mg/kg b.w) served as positive control.
GE-treated groups showed significantly reduced body weight, serum lipid, and liver enzymes levels.
GE also attenuated protein carbonyl and lipid hydroperoxide levels by increasing the enzymic antioxidants (SOD, CAT, and GPx) activities in the mice.
GE-treated groups induced the expression of hormone sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) while downregulated the expression of peroxisome proliferator-activated receptor gamma (PPAR-γ), sterol regulatory binding protein-1c (SREBP-1c), and lipoprotein lipase (LPL).
Hence, GE prevented weight gain in the mice by inducing lipolysis and may be valuable in the formulation of adjuvant therapy for obesity.
American Psychological Association (APA)
Kanagasabapathy, Gowri& Abd Malek, Sri Nurestri& Abdulla, Mahmood Ameen& Chua, Kek Heng& Sabaratnam, Vikineswary& Kuppusamy, Umah Rani. 2013. Beta-Glucan-Rich Extract from Pleurotus sajor-caju (Fr.) Singer Prevents Obesity and Oxidative Stress in C57BL6J Mice Fed on a High-Fat Diet. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-452754
Modern Language Association (MLA)
Kanagasabapathy, Gowri…[et al.]. Beta-Glucan-Rich Extract from Pleurotus sajor-caju (Fr.) Singer Prevents Obesity and Oxidative Stress in C57BL6J Mice Fed on a High-Fat Diet. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-452754
American Medical Association (AMA)
Kanagasabapathy, Gowri& Abd Malek, Sri Nurestri& Abdulla, Mahmood Ameen& Chua, Kek Heng& Sabaratnam, Vikineswary& Kuppusamy, Umah Rani. Beta-Glucan-Rich Extract from Pleurotus sajor-caju (Fr.) Singer Prevents Obesity and Oxidative Stress in C57BL6J Mice Fed on a High-Fat Diet. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-452754
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452754