Neither MICA Nor DEPDC5 Genetic Polymorphisms Correlate with Hepatocellular Carcinoma Recurrence following Hepatectomy

المؤلفون المشاركون

Shirabe, Ken
Toshima, Takeo
Ikegami, Toru
Konishi, Hideyuki
Yoshizumi, Tomoharu
Ono, Yuki
Fukuhara, Takasuke
Maehara, Yoshihiko
Yoshiya, Shohei
Muto, Jun
Mano, Yohei
Motomura, Takashi

المصدر

HPB Surgery

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-10-24

دولة النشر

مصر

عدد الصفحات

6

التخصصات الرئيسية

الطب البشري

الملخص EN

Purpose.

Genetic polymorphisms of MICA and DEPDC5 have been reported to correlate with progression to hepatocellular carcinoma (HCC) in chronic hepatitis C patients.

However, correlation of these genetic variants with HCC recurrence following hepatectomy has not yet been clarified.

Methods.

Ninety-six consecutive HCC patients who underwent hepatectomy, including 64 patients who were hepatitis C virus (HCV) positive, were genotyped for MICA (rs2596542) and DEPDC5 (rs1012068).

Recurrence-free survival rates (RFS) were compared for each genotype.

Results.

Five-year HCC recurrence-free survival (RFS) rates following hepatectomy were 20.7% in MICA GG allele carriers, 38.7% in GA, and 20.8% in AA, respectively (P=0.72).

The five-year RFS rate was 23.8% in DEPDC5 TT allele carriers and 31.8% in TG/GG, respectively (P=0.47).

The survival rates in all (including HCV-negative) patients were also similar among each MICA and DEPDC5 genotype following hepatectomy.

Among HCV-positive patients carrying the DEPDC5 TG/GG allele, low fibrosis stage (F0-2) occurred more often compared with TT carriers (P<0.05).

Conclusions.

Neither MICA nor DEPDC5 genetic polymorphism correlates with HCC recurrence following hepatectomy.

DEPDC5 minor genotype data suggest a high susceptibility for HCC development in livers, even those with low fibrosis stages.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Motomura, Takashi& Ono, Yuki& Shirabe, Ken& Fukuhara, Takasuke& Konishi, Hideyuki& Mano, Yohei…[et al.]. 2012. Neither MICA Nor DEPDC5 Genetic Polymorphisms Correlate with Hepatocellular Carcinoma Recurrence following Hepatectomy. HPB Surgery،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-452788

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Motomura, Takashi…[et al.]. Neither MICA Nor DEPDC5 Genetic Polymorphisms Correlate with Hepatocellular Carcinoma Recurrence following Hepatectomy. HPB Surgery No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-452788

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Motomura, Takashi& Ono, Yuki& Shirabe, Ken& Fukuhara, Takasuke& Konishi, Hideyuki& Mano, Yohei…[et al.]. Neither MICA Nor DEPDC5 Genetic Polymorphisms Correlate with Hepatocellular Carcinoma Recurrence following Hepatectomy. HPB Surgery. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-452788

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-452788