Neither MICA Nor DEPDC5 Genetic Polymorphisms Correlate with Hepatocellular Carcinoma Recurrence following Hepatectomy
Joint Authors
Shirabe, Ken
Toshima, Takeo
Ikegami, Toru
Konishi, Hideyuki
Yoshizumi, Tomoharu
Ono, Yuki
Fukuhara, Takasuke
Maehara, Yoshihiko
Yoshiya, Shohei
Muto, Jun
Mano, Yohei
Motomura, Takashi
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
Genetic polymorphisms of MICA and DEPDC5 have been reported to correlate with progression to hepatocellular carcinoma (HCC) in chronic hepatitis C patients.
However, correlation of these genetic variants with HCC recurrence following hepatectomy has not yet been clarified.
Methods.
Ninety-six consecutive HCC patients who underwent hepatectomy, including 64 patients who were hepatitis C virus (HCV) positive, were genotyped for MICA (rs2596542) and DEPDC5 (rs1012068).
Recurrence-free survival rates (RFS) were compared for each genotype.
Results.
Five-year HCC recurrence-free survival (RFS) rates following hepatectomy were 20.7% in MICA GG allele carriers, 38.7% in GA, and 20.8% in AA, respectively (P=0.72).
The five-year RFS rate was 23.8% in DEPDC5 TT allele carriers and 31.8% in TG/GG, respectively (P=0.47).
The survival rates in all (including HCV-negative) patients were also similar among each MICA and DEPDC5 genotype following hepatectomy.
Among HCV-positive patients carrying the DEPDC5 TG/GG allele, low fibrosis stage (F0-2) occurred more often compared with TT carriers (P<0.05).
Conclusions.
Neither MICA nor DEPDC5 genetic polymorphism correlates with HCC recurrence following hepatectomy.
DEPDC5 minor genotype data suggest a high susceptibility for HCC development in livers, even those with low fibrosis stages.
American Psychological Association (APA)
Motomura, Takashi& Ono, Yuki& Shirabe, Ken& Fukuhara, Takasuke& Konishi, Hideyuki& Mano, Yohei…[et al.]. 2012. Neither MICA Nor DEPDC5 Genetic Polymorphisms Correlate with Hepatocellular Carcinoma Recurrence following Hepatectomy. HPB Surgery،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-452788
Modern Language Association (MLA)
Motomura, Takashi…[et al.]. Neither MICA Nor DEPDC5 Genetic Polymorphisms Correlate with Hepatocellular Carcinoma Recurrence following Hepatectomy. HPB Surgery No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-452788
American Medical Association (AMA)
Motomura, Takashi& Ono, Yuki& Shirabe, Ken& Fukuhara, Takasuke& Konishi, Hideyuki& Mano, Yohei…[et al.]. Neither MICA Nor DEPDC5 Genetic Polymorphisms Correlate with Hepatocellular Carcinoma Recurrence following Hepatectomy. HPB Surgery. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-452788
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452788