Pathology-Dependent Effects Linked to Small Heat Shock Proteins Expression : An Update
المؤلف
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-11-18
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأمراض
الملخص EN
Small heat shock proteins (small Hsps) are stress-induced molecular chaperones that act as holdases towards polypeptides that have lost their folding in stress conditions or consequently of mutations in their coding sequence.
A cellular protection against the deleterious effects mediated by damaged proteins is thus provided to cells.
These chaperones are also highly expressed in response to protein conformational and inflammatory diseases and cancer pathologies.
Through specific and reversible modifications in their phospho-oligomeric organization, small Hsps can chaperone appropriate client proteins in order to provide cells with resistance to different types of injuries or pathological conditions.
By helping cells to better cope with their pathological status, their expression can be either beneficial, such as in diseases characterized by pathological cell degeneration, or deleterious when they are required for tumor cell survival.
Moreover, small Hsps are actively released by cells and can act as immunogenic molecules that have dual effects depending on the pathology.
The cellular consequences linked to their expression levels and relationships with other Hsps as well as therapeutic strategies are discussed in view of their dynamic structural organization required to interact with specific client polypeptides.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Arrigo, A.-P.. 2012. Pathology-Dependent Effects Linked to Small Heat Shock Proteins Expression : An Update. Scientifica،Vol. 2012, no. 2012, pp.1-19.
https://search.emarefa.net/detail/BIM-452795
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Arrigo, A.-P.. Pathology-Dependent Effects Linked to Small Heat Shock Proteins Expression : An Update. Scientifica No. 2012 (2012), pp.1-19.
https://search.emarefa.net/detail/BIM-452795
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Arrigo, A.-P.. Pathology-Dependent Effects Linked to Small Heat Shock Proteins Expression : An Update. Scientifica. 2012. Vol. 2012, no. 2012, pp.1-19.
https://search.emarefa.net/detail/BIM-452795
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-452795
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر