Pathology-Dependent Effects Linked to Small Heat Shock Proteins Expression : An Update
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-18
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Diseases
Abstract EN
Small heat shock proteins (small Hsps) are stress-induced molecular chaperones that act as holdases towards polypeptides that have lost their folding in stress conditions or consequently of mutations in their coding sequence.
A cellular protection against the deleterious effects mediated by damaged proteins is thus provided to cells.
These chaperones are also highly expressed in response to protein conformational and inflammatory diseases and cancer pathologies.
Through specific and reversible modifications in their phospho-oligomeric organization, small Hsps can chaperone appropriate client proteins in order to provide cells with resistance to different types of injuries or pathological conditions.
By helping cells to better cope with their pathological status, their expression can be either beneficial, such as in diseases characterized by pathological cell degeneration, or deleterious when they are required for tumor cell survival.
Moreover, small Hsps are actively released by cells and can act as immunogenic molecules that have dual effects depending on the pathology.
The cellular consequences linked to their expression levels and relationships with other Hsps as well as therapeutic strategies are discussed in view of their dynamic structural organization required to interact with specific client polypeptides.
American Psychological Association (APA)
Arrigo, A.-P.. 2012. Pathology-Dependent Effects Linked to Small Heat Shock Proteins Expression : An Update. Scientifica،Vol. 2012, no. 2012, pp.1-19.
https://search.emarefa.net/detail/BIM-452795
Modern Language Association (MLA)
Arrigo, A.-P.. Pathology-Dependent Effects Linked to Small Heat Shock Proteins Expression : An Update. Scientifica No. 2012 (2012), pp.1-19.
https://search.emarefa.net/detail/BIM-452795
American Medical Association (AMA)
Arrigo, A.-P.. Pathology-Dependent Effects Linked to Small Heat Shock Proteins Expression : An Update. Scientifica. 2012. Vol. 2012, no. 2012, pp.1-19.
https://search.emarefa.net/detail/BIM-452795
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452795