Inbuilt Mechanisms for Overcoming Functional Problems Inherent in Hepatic Microlobular Structure
المؤلفون المشاركون
Boucher, Barbara J.
Cohen, Robert D.
Wang, Wen
Nickols, Carole
Levey, Pauline
Brown, Christopher L.
Greenwald, Stephen E.
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-03-28
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The spherical anatomy of human and rat liver lobules implies that more central cells have less time to carry out their function than more peripherally located cells because blood flows past them more rapidly.
This problem could be overcome if more centrilobular cells could operate at higher temperatures than periportal cells.
This study presents evidence for such a temperature gradient.
Firstly, we use mathematical modelling to demonstrate that temperature increases towards the centre of the lobule.
Secondly, we examine the distribution of a heat-generating protein and of a heat-sensitive protein across the rat and human liver lobules.
Double-antibody staining of healthy liver from rat and human was used for visual scoring and for automated histomorphometric quantitation of the localisation of uncoupling protein-2 (known to generate heat) and of the transient receptor potential-v4 protein (known as a highly temperature-sensitive membrane protein).
Both these proteins were found to be located predominantly in the centrilobular region of liver lobules.
These findings support the suggestion that temperature gradients across the liver lobule may have evolved as a solution to the problem of reduced contact time between blood and cells at the centre as compared to the periphery of mammalian liver lobules.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cohen, Robert D.& Brown, Christopher L.& Nickols, Carole& Levey, Pauline& Boucher, Barbara J.& Greenwald, Stephen E.…[et al.]. 2011. Inbuilt Mechanisms for Overcoming Functional Problems Inherent in Hepatic Microlobular Structure. Computational and Mathematical Methods in Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-452821
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cohen, Robert D.…[et al.]. Inbuilt Mechanisms for Overcoming Functional Problems Inherent in Hepatic Microlobular Structure. Computational and Mathematical Methods in Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-452821
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cohen, Robert D.& Brown, Christopher L.& Nickols, Carole& Levey, Pauline& Boucher, Barbara J.& Greenwald, Stephen E.…[et al.]. Inbuilt Mechanisms for Overcoming Functional Problems Inherent in Hepatic Microlobular Structure. Computational and Mathematical Methods in Medicine. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-452821
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-452821
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر