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Inbuilt Mechanisms for Overcoming Functional Problems Inherent in Hepatic Microlobular Structure
Joint Authors
Boucher, Barbara J.
Cohen, Robert D.
Wang, Wen
Nickols, Carole
Levey, Pauline
Brown, Christopher L.
Greenwald, Stephen E.
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The spherical anatomy of human and rat liver lobules implies that more central cells have less time to carry out their function than more peripherally located cells because blood flows past them more rapidly.
This problem could be overcome if more centrilobular cells could operate at higher temperatures than periportal cells.
This study presents evidence for such a temperature gradient.
Firstly, we use mathematical modelling to demonstrate that temperature increases towards the centre of the lobule.
Secondly, we examine the distribution of a heat-generating protein and of a heat-sensitive protein across the rat and human liver lobules.
Double-antibody staining of healthy liver from rat and human was used for visual scoring and for automated histomorphometric quantitation of the localisation of uncoupling protein-2 (known to generate heat) and of the transient receptor potential-v4 protein (known as a highly temperature-sensitive membrane protein).
Both these proteins were found to be located predominantly in the centrilobular region of liver lobules.
These findings support the suggestion that temperature gradients across the liver lobule may have evolved as a solution to the problem of reduced contact time between blood and cells at the centre as compared to the periphery of mammalian liver lobules.
American Psychological Association (APA)
Cohen, Robert D.& Brown, Christopher L.& Nickols, Carole& Levey, Pauline& Boucher, Barbara J.& Greenwald, Stephen E.…[et al.]. 2011. Inbuilt Mechanisms for Overcoming Functional Problems Inherent in Hepatic Microlobular Structure. Computational and Mathematical Methods in Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-452821
Modern Language Association (MLA)
Cohen, Robert D.…[et al.]. Inbuilt Mechanisms for Overcoming Functional Problems Inherent in Hepatic Microlobular Structure. Computational and Mathematical Methods in Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-452821
American Medical Association (AMA)
Cohen, Robert D.& Brown, Christopher L.& Nickols, Carole& Levey, Pauline& Boucher, Barbara J.& Greenwald, Stephen E.…[et al.]. Inbuilt Mechanisms for Overcoming Functional Problems Inherent in Hepatic Microlobular Structure. Computational and Mathematical Methods in Medicine. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-452821
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452821