Location, Location, Location : Is Membrane Partitioning Everything When It Comes to Innate Immune Activation?
المؤلفون المشاركون
Olden, Robin
Lepper, Philipp M.
Triantafilou, Martha
Dias, Ivo de Seabra Rodrigues
Triantafilou, Kathy
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-06-21
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
In the last twenty years, the general view of the plasma membrane has changed from a homogeneous arrangement of lipids to a mosaic of microdomains.
It is currently thought that islands of highly ordered saturated lipids and cholesterol, which are laterally mobile, exist in the plane of the plasma membrane.
Lipid rafts are thought to provide a means to explain the spatial segregation of certain signalling pathways emanating from the cell surface.
They seem to provide the necessary microenvironment in order for certain specialised signalling events to take place, such as the innate immune recognition.
The innate immune system seems to employ germ-lined encoded receptors, called pattern recognition receptors (PRRs), in order to detect pathogens.
One family of such receptors are the Toll-like receptors (TLRs), which are the central “sensing” apparatus of the innate immune system.
In recent years, it has become apparent that TLRs are recruited into membrane microdomains in response to ligands.
These nanoscale assemblies of sphingolipid, cholesterol, and TLRs stabilize and coalesce, forming signalling platforms, which transduce signals that lead to innate immune activation.
In the current paper, we will investigate all past and current literature concerning recruitment of extracellular and intracellular TLRs into lipid rafts and how this membrane organization modulates innate immune responses.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Triantafilou, Martha& Lepper, Philipp M.& Olden, Robin& Dias, Ivo de Seabra Rodrigues& Triantafilou, Kathy. 2011. Location, Location, Location : Is Membrane Partitioning Everything When It Comes to Innate Immune Activation?. Mediators of Inflammation،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-452851
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Triantafilou, Martha…[et al.]. Location, Location, Location : Is Membrane Partitioning Everything When It Comes to Innate Immune Activation?. Mediators of Inflammation No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-452851
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Triantafilou, Martha& Lepper, Philipp M.& Olden, Robin& Dias, Ivo de Seabra Rodrigues& Triantafilou, Kathy. Location, Location, Location : Is Membrane Partitioning Everything When It Comes to Innate Immune Activation?. Mediators of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-452851
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-452851
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر