Location, Location, Location : Is Membrane Partitioning Everything When It Comes to Innate Immune Activation?
Joint Authors
Olden, Robin
Lepper, Philipp M.
Triantafilou, Martha
Dias, Ivo de Seabra Rodrigues
Triantafilou, Kathy
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
In the last twenty years, the general view of the plasma membrane has changed from a homogeneous arrangement of lipids to a mosaic of microdomains.
It is currently thought that islands of highly ordered saturated lipids and cholesterol, which are laterally mobile, exist in the plane of the plasma membrane.
Lipid rafts are thought to provide a means to explain the spatial segregation of certain signalling pathways emanating from the cell surface.
They seem to provide the necessary microenvironment in order for certain specialised signalling events to take place, such as the innate immune recognition.
The innate immune system seems to employ germ-lined encoded receptors, called pattern recognition receptors (PRRs), in order to detect pathogens.
One family of such receptors are the Toll-like receptors (TLRs), which are the central “sensing” apparatus of the innate immune system.
In recent years, it has become apparent that TLRs are recruited into membrane microdomains in response to ligands.
These nanoscale assemblies of sphingolipid, cholesterol, and TLRs stabilize and coalesce, forming signalling platforms, which transduce signals that lead to innate immune activation.
In the current paper, we will investigate all past and current literature concerning recruitment of extracellular and intracellular TLRs into lipid rafts and how this membrane organization modulates innate immune responses.
American Psychological Association (APA)
Triantafilou, Martha& Lepper, Philipp M.& Olden, Robin& Dias, Ivo de Seabra Rodrigues& Triantafilou, Kathy. 2011. Location, Location, Location : Is Membrane Partitioning Everything When It Comes to Innate Immune Activation?. Mediators of Inflammation،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-452851
Modern Language Association (MLA)
Triantafilou, Martha…[et al.]. Location, Location, Location : Is Membrane Partitioning Everything When It Comes to Innate Immune Activation?. Mediators of Inflammation No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-452851
American Medical Association (AMA)
Triantafilou, Martha& Lepper, Philipp M.& Olden, Robin& Dias, Ivo de Seabra Rodrigues& Triantafilou, Kathy. Location, Location, Location : Is Membrane Partitioning Everything When It Comes to Innate Immune Activation?. Mediators of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-452851
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452851