Adaptive Redox Response of Mesenchymal Stromal Cells to Stimulation with Lipopolysaccharide Inflammagen : Mechanisms of Remodeling of Tissue Barriers in Sepsis
المؤلفون المشاركون
Kiang, Juliann G.
Garrison, Bradley R.
McDaniel, Dennis P.
Gorbunov, Nikolai V.
Nurmemet, Dilber
Liao, Pei-Jyun
Zhai, Min
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-18
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Acute bacterial inflammation is accompanied by excessive release of bacterial toxins and production of reactive oxygen and nitrogen species (ROS and RNS), which ultimately results in redox stress.
These factors can induce damage to components of tissue barriers, including damage to ubiquitous mesenchymal stromal cells (MSCs), and thus can exacerbate the septic multiple organ dysfunctions.
The mechanisms employed by MSCs in order to survive these stress conditions are still poorly understood and require clarification.
In this report, we demonstrated that in vitro treatment of MSCs with lipopolysaccharide (LPS) induced inflammatory responses, which included, but not limited to, upregulation of iNOS and release of RNS and ROS.
These events triggered in MSCs a cascade of responses driving adaptive remodeling and resistance to a “self-inflicted” oxidative stress.
Thus, while MSCs displayed high levels of constitutively present adaptogens, for example, HSP70 and mitochondrial Sirt3, treatment with LPS induced a number of adaptive responses that included induction and nuclear translocation of redox response elements such as NFkB, TRX1, Ref1, Nrf2, FoxO3a, HO1, and activation of autophagy and mitochondrial remodeling.
We propose that the above prosurvival pathways activated in MSCs in vitro could be a part of adaptive responses employed by stromal cells under septic conditions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gorbunov, Nikolai V.& Garrison, Bradley R.& McDaniel, Dennis P.& Zhai, Min& Liao, Pei-Jyun& Nurmemet, Dilber…[et al.]. 2013. Adaptive Redox Response of Mesenchymal Stromal Cells to Stimulation with Lipopolysaccharide Inflammagen : Mechanisms of Remodeling of Tissue Barriers in Sepsis. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-452914
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gorbunov, Nikolai V.…[et al.]. Adaptive Redox Response of Mesenchymal Stromal Cells to Stimulation with Lipopolysaccharide Inflammagen : Mechanisms of Remodeling of Tissue Barriers in Sepsis. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-452914
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gorbunov, Nikolai V.& Garrison, Bradley R.& McDaniel, Dennis P.& Zhai, Min& Liao, Pei-Jyun& Nurmemet, Dilber…[et al.]. Adaptive Redox Response of Mesenchymal Stromal Cells to Stimulation with Lipopolysaccharide Inflammagen : Mechanisms of Remodeling of Tissue Barriers in Sepsis. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-452914
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-452914
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر