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Adaptive Redox Response of Mesenchymal Stromal Cells to Stimulation with Lipopolysaccharide Inflammagen : Mechanisms of Remodeling of Tissue Barriers in Sepsis
Joint Authors
Kiang, Juliann G.
Garrison, Bradley R.
McDaniel, Dennis P.
Gorbunov, Nikolai V.
Nurmemet, Dilber
Liao, Pei-Jyun
Zhai, Min
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-18
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Acute bacterial inflammation is accompanied by excessive release of bacterial toxins and production of reactive oxygen and nitrogen species (ROS and RNS), which ultimately results in redox stress.
These factors can induce damage to components of tissue barriers, including damage to ubiquitous mesenchymal stromal cells (MSCs), and thus can exacerbate the septic multiple organ dysfunctions.
The mechanisms employed by MSCs in order to survive these stress conditions are still poorly understood and require clarification.
In this report, we demonstrated that in vitro treatment of MSCs with lipopolysaccharide (LPS) induced inflammatory responses, which included, but not limited to, upregulation of iNOS and release of RNS and ROS.
These events triggered in MSCs a cascade of responses driving adaptive remodeling and resistance to a “self-inflicted” oxidative stress.
Thus, while MSCs displayed high levels of constitutively present adaptogens, for example, HSP70 and mitochondrial Sirt3, treatment with LPS induced a number of adaptive responses that included induction and nuclear translocation of redox response elements such as NFkB, TRX1, Ref1, Nrf2, FoxO3a, HO1, and activation of autophagy and mitochondrial remodeling.
We propose that the above prosurvival pathways activated in MSCs in vitro could be a part of adaptive responses employed by stromal cells under septic conditions.
American Psychological Association (APA)
Gorbunov, Nikolai V.& Garrison, Bradley R.& McDaniel, Dennis P.& Zhai, Min& Liao, Pei-Jyun& Nurmemet, Dilber…[et al.]. 2013. Adaptive Redox Response of Mesenchymal Stromal Cells to Stimulation with Lipopolysaccharide Inflammagen : Mechanisms of Remodeling of Tissue Barriers in Sepsis. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-452914
Modern Language Association (MLA)
Gorbunov, Nikolai V.…[et al.]. Adaptive Redox Response of Mesenchymal Stromal Cells to Stimulation with Lipopolysaccharide Inflammagen : Mechanisms of Remodeling of Tissue Barriers in Sepsis. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-452914
American Medical Association (AMA)
Gorbunov, Nikolai V.& Garrison, Bradley R.& McDaniel, Dennis P.& Zhai, Min& Liao, Pei-Jyun& Nurmemet, Dilber…[et al.]. Adaptive Redox Response of Mesenchymal Stromal Cells to Stimulation with Lipopolysaccharide Inflammagen : Mechanisms of Remodeling of Tissue Barriers in Sepsis. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-452914
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452914