Inhibition of Cathepsin S Produces Neuroprotective Effects after Traumatic Brain Injury in Mice
المؤلفون المشاركون
Lu, Xinyu
Li, Tao
Wang, Handong
Xu, Jianguo
Ding, Ke
Wang, Jiawei
Wang, Jian
Wang, Chunxi
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-24
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Cathepsin S (CatS) is a cysteine protease normally present in lysosomes.
It has long been regarded as an enzyme that is primarily involved in general protein degradation.
More recently, mounting evidence has shown that it is involved in Alzheimer disease, seizures, age-related inflammatory processes, and neuropathic pain.
In this study, we investigated the time course of CatS protein and mRNA expression and the cellular distribution of CatS in a mouse model of traumatic brain injury (TBI).
To clarify the roles of CatS in TBI, we injected the mice intraventricularly with LHVS, a nonbrain penetrant, irreversible CatS inhibitor, and examined the effect on inflammation and neurobehavioral function.
We found that expression of CatS was increased as early as 1 h after TBI at both protein and mRNA levels.
The increased expression was detected in microglia and neurons.
Inhibition of CatS significantly reduced the level of TBI-induced inflammatory factors in brain tissue and alleviated brain edema.
Additionally, administration of LHVS led to a decrease in neuronal degeneration and improved neurobehavioral function.
These results imply that CatS is involved in the secondary injury after TBI and provide a new perspective for preventing secondary injury after TBI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Jianguo& Wang, Handong& Ding, Ke& Lu, Xinyu& Li, Tao& Wang, Jiawei…[et al.]. 2013. Inhibition of Cathepsin S Produces Neuroprotective Effects after Traumatic Brain Injury in Mice. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-453018
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Jianguo…[et al.]. Inhibition of Cathepsin S Produces Neuroprotective Effects after Traumatic Brain Injury in Mice. Mediators of Inflammation No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-453018
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Jianguo& Wang, Handong& Ding, Ke& Lu, Xinyu& Li, Tao& Wang, Jiawei…[et al.]. Inhibition of Cathepsin S Produces Neuroprotective Effects after Traumatic Brain Injury in Mice. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-453018
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-453018
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر