Inhibition of Cathepsin S Produces Neuroprotective Effects after Traumatic Brain Injury in Mice
Joint Authors
Lu, Xinyu
Li, Tao
Wang, Handong
Xu, Jianguo
Ding, Ke
Wang, Jiawei
Wang, Jian
Wang, Chunxi
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Cathepsin S (CatS) is a cysteine protease normally present in lysosomes.
It has long been regarded as an enzyme that is primarily involved in general protein degradation.
More recently, mounting evidence has shown that it is involved in Alzheimer disease, seizures, age-related inflammatory processes, and neuropathic pain.
In this study, we investigated the time course of CatS protein and mRNA expression and the cellular distribution of CatS in a mouse model of traumatic brain injury (TBI).
To clarify the roles of CatS in TBI, we injected the mice intraventricularly with LHVS, a nonbrain penetrant, irreversible CatS inhibitor, and examined the effect on inflammation and neurobehavioral function.
We found that expression of CatS was increased as early as 1 h after TBI at both protein and mRNA levels.
The increased expression was detected in microglia and neurons.
Inhibition of CatS significantly reduced the level of TBI-induced inflammatory factors in brain tissue and alleviated brain edema.
Additionally, administration of LHVS led to a decrease in neuronal degeneration and improved neurobehavioral function.
These results imply that CatS is involved in the secondary injury after TBI and provide a new perspective for preventing secondary injury after TBI.
American Psychological Association (APA)
Xu, Jianguo& Wang, Handong& Ding, Ke& Lu, Xinyu& Li, Tao& Wang, Jiawei…[et al.]. 2013. Inhibition of Cathepsin S Produces Neuroprotective Effects after Traumatic Brain Injury in Mice. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-453018
Modern Language Association (MLA)
Xu, Jianguo…[et al.]. Inhibition of Cathepsin S Produces Neuroprotective Effects after Traumatic Brain Injury in Mice. Mediators of Inflammation No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-453018
American Medical Association (AMA)
Xu, Jianguo& Wang, Handong& Ding, Ke& Lu, Xinyu& Li, Tao& Wang, Jiawei…[et al.]. Inhibition of Cathepsin S Produces Neuroprotective Effects after Traumatic Brain Injury in Mice. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-453018
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453018