Use of Ghrelin as a Treatment for Inflammatory Bowel Disease : Mechanistic Considerations

المؤلف

DeBoer, Mark D.

المصدر

International Journal of Peptides

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-08-09

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الكيمياء

الملخص EN

Inflammatory bowel diseases (IBD)—and in particular Crohn's disease—are immune-mediated processes that result in denuded intestinal mucosa and can produce decreased appetite, weight loss, and systemic inflammation.

Current treatments include anti-inflammatory medications, immunomodulators, and feeding interventions.

Ghrelin is an endogenous orexigenic hormone that directly stimulates growth hormone release, increases gut motility, and has cardiovascular and anti-inflammatory properties.

Although ghrelin levels are elevated in active IBD, administration of ghrelin in most (but not all) animal models of colitis has produced improvements in disease activity and systemic inflammation.

The mechanism for these effects is not known but may relate to decreased inflammation, increased motility, increased appetite, and increased colonic blood flow.

Human trials have not been performed, however, and more research is clearly needed.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

DeBoer, Mark D.. 2011. Use of Ghrelin as a Treatment for Inflammatory Bowel Disease : Mechanistic Considerations. International Journal of Peptides،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-453055

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

DeBoer, Mark D.. Use of Ghrelin as a Treatment for Inflammatory Bowel Disease : Mechanistic Considerations. International Journal of Peptides No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-453055

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

DeBoer, Mark D.. Use of Ghrelin as a Treatment for Inflammatory Bowel Disease : Mechanistic Considerations. International Journal of Peptides. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-453055

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-453055