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Use of Ghrelin as a Treatment for Inflammatory Bowel Disease : Mechanistic Considerations
Author
Source
International Journal of Peptides
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Inflammatory bowel diseases (IBD)—and in particular Crohn's disease—are immune-mediated processes that result in denuded intestinal mucosa and can produce decreased appetite, weight loss, and systemic inflammation.
Current treatments include anti-inflammatory medications, immunomodulators, and feeding interventions.
Ghrelin is an endogenous orexigenic hormone that directly stimulates growth hormone release, increases gut motility, and has cardiovascular and anti-inflammatory properties.
Although ghrelin levels are elevated in active IBD, administration of ghrelin in most (but not all) animal models of colitis has produced improvements in disease activity and systemic inflammation.
The mechanism for these effects is not known but may relate to decreased inflammation, increased motility, increased appetite, and increased colonic blood flow.
Human trials have not been performed, however, and more research is clearly needed.
American Psychological Association (APA)
DeBoer, Mark D.. 2011. Use of Ghrelin as a Treatment for Inflammatory Bowel Disease : Mechanistic Considerations. International Journal of Peptides،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-453055
Modern Language Association (MLA)
DeBoer, Mark D.. Use of Ghrelin as a Treatment for Inflammatory Bowel Disease : Mechanistic Considerations. International Journal of Peptides No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-453055
American Medical Association (AMA)
DeBoer, Mark D.. Use of Ghrelin as a Treatment for Inflammatory Bowel Disease : Mechanistic Considerations. International Journal of Peptides. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-453055
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453055