Prenatal and Postnatal Epigenetic Programming : Implications for GI, Immune, and Neuronal Function in Autism
المؤلفون المشاركون
Trivedi, Malav
Waly, Mostafa I.
Kini, Radhika
Hornig, Mady
Deth, Richard C.
Ohta, Akio
Hodgson, Nathaniel
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-19
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Although autism is first and foremost a disorder of the central nervous system, comorbid dysfunction of the gastrointestinal (GI) and immune systems is common, suggesting that all three systems may be affected by common molecular mechanisms.
Substantial systemic deficits in the antioxidant glutathione and its precursor, cysteine, have been documented in autism in association with oxidative stress and impaired methylation.
DNA and histone methylation provide epigenetic regulation of gene expression during prenatal and postnatal development.
Prenatal epigenetic programming (PrEP) can be affected by the maternal metabolic and nutritional environment, whereas postnatal epigenetic programming (PEP) importantly depends upon nutritional support provided through the GI tract.
Cysteine absorption from the GI tract is a crucial determinant of antioxidant capacity, and systemic deficits of glutathione and cysteine in autism are likely to reflect impaired cysteine absorption.
Excitatory amino acid transporter 3 (EAAT3) provides cysteine uptake for GI epithelial, neuronal, and immune cells, and its activity is decreased during oxidative stress.
Based upon these observations, we propose that neurodevelopmental, GI, and immune aspects of autism each reflect manifestations of inadequate antioxidant capacity, secondary to impaired cysteine uptake by the GI tract.
Genetic and environmental factors that adversely affect antioxidant capacity can disrupt PrEP and/or PEP, increasing vulnerability to autism.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Waly, Mostafa I.& Hornig, Mady& Trivedi, Malav& Hodgson, Nathaniel& Kini, Radhika& Ohta, Akio…[et al.]. 2012. Prenatal and Postnatal Epigenetic Programming : Implications for GI, Immune, and Neuronal Function in Autism. Autism Research and Treatment،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-453203
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Waly, Mostafa I.…[et al.]. Prenatal and Postnatal Epigenetic Programming : Implications for GI, Immune, and Neuronal Function in Autism. Autism Research and Treatment No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-453203
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Waly, Mostafa I.& Hornig, Mady& Trivedi, Malav& Hodgson, Nathaniel& Kini, Radhika& Ohta, Akio…[et al.]. Prenatal and Postnatal Epigenetic Programming : Implications for GI, Immune, and Neuronal Function in Autism. Autism Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-453203
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-453203
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر