Pistacia chinensis : A Potent Ameliorator of CCl4 Induced Lung and Thyroid Toxicity in Rat Model
المؤلفون المشاركون
Shah, Naseer Ali
Noureen, Farah
Khan, Muhammad Rashid
Naz, Kiran
Awan, Madeeha Latif
Sattar, Saadia
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-11
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
In the current study protective effect of ethanol extract of Pistacia chinensis bark (PCEB) was investigated in rats against CCl4 induced lung and thyroid injuries.
PCEB dose dependently inhibited the rise of thiobarbituric acid-reactive substances, hydrogen peroxide, nitrite, and protein content and restored the levels of antioxidant enzymes, that is, catalase, peroxidase, superoxide dismutase, glutathione-S-transferase, glutathione reductase, glutathione peroxidase, γ-glutamyl transpeptidase, and quinone reductase in both lung and thyroid tissues of CCl4 treated rats.
Decrease in number of leukocytes, neutrophils, and hemoglobin and T3 and T4 content as well as increase in monocytes, eosinophils, and lymphocytes count with CCl4 were restored to normal level with PCEB treatment.
Histological study of CCl4 treated rats showed various lung injuries like rupture of alveolar walls and bronchioles, aggregation of fibroblasts, and disorganized Clara cells.
Similarly, histology of CCl4 treated thyroid tissues displayed damaged thyroid follicles, hypertrophy, and colloidal depletion.
However, PCEB exhibited protective behaviour for lungs and thyroid, with improved histological structure in a dose dependant manner.
Presence of three known phenolic compounds, that is, rutin, tannin, and gallic acid, and three unknown compounds was verified in thin layer chromatographic assessment of PCEB.
In conclusion, P.
chinensis exhibited antioxidant activity by the presence of free radical quenching constituents.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Naz, Kiran& Khan, Muhammad Rashid& Shah, Naseer Ali& Sattar, Saadia& Noureen, Farah& Awan, Madeeha Latif. 2014. Pistacia chinensis : A Potent Ameliorator of CCl4 Induced Lung and Thyroid Toxicity in Rat Model. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-453365
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Naz, Kiran…[et al.]. Pistacia chinensis : A Potent Ameliorator of CCl4 Induced Lung and Thyroid Toxicity in Rat Model. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-453365
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Naz, Kiran& Khan, Muhammad Rashid& Shah, Naseer Ali& Sattar, Saadia& Noureen, Farah& Awan, Madeeha Latif. Pistacia chinensis : A Potent Ameliorator of CCl4 Induced Lung and Thyroid Toxicity in Rat Model. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-453365
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-453365
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر