Pistacia chinensis : A Potent Ameliorator of CCl4 Induced Lung and Thyroid Toxicity in Rat Model
Joint Authors
Shah, Naseer Ali
Noureen, Farah
Khan, Muhammad Rashid
Naz, Kiran
Awan, Madeeha Latif
Sattar, Saadia
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-11
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
In the current study protective effect of ethanol extract of Pistacia chinensis bark (PCEB) was investigated in rats against CCl4 induced lung and thyroid injuries.
PCEB dose dependently inhibited the rise of thiobarbituric acid-reactive substances, hydrogen peroxide, nitrite, and protein content and restored the levels of antioxidant enzymes, that is, catalase, peroxidase, superoxide dismutase, glutathione-S-transferase, glutathione reductase, glutathione peroxidase, γ-glutamyl transpeptidase, and quinone reductase in both lung and thyroid tissues of CCl4 treated rats.
Decrease in number of leukocytes, neutrophils, and hemoglobin and T3 and T4 content as well as increase in monocytes, eosinophils, and lymphocytes count with CCl4 were restored to normal level with PCEB treatment.
Histological study of CCl4 treated rats showed various lung injuries like rupture of alveolar walls and bronchioles, aggregation of fibroblasts, and disorganized Clara cells.
Similarly, histology of CCl4 treated thyroid tissues displayed damaged thyroid follicles, hypertrophy, and colloidal depletion.
However, PCEB exhibited protective behaviour for lungs and thyroid, with improved histological structure in a dose dependant manner.
Presence of three known phenolic compounds, that is, rutin, tannin, and gallic acid, and three unknown compounds was verified in thin layer chromatographic assessment of PCEB.
In conclusion, P.
chinensis exhibited antioxidant activity by the presence of free radical quenching constituents.
American Psychological Association (APA)
Naz, Kiran& Khan, Muhammad Rashid& Shah, Naseer Ali& Sattar, Saadia& Noureen, Farah& Awan, Madeeha Latif. 2014. Pistacia chinensis : A Potent Ameliorator of CCl4 Induced Lung and Thyroid Toxicity in Rat Model. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-453365
Modern Language Association (MLA)
Naz, Kiran…[et al.]. Pistacia chinensis : A Potent Ameliorator of CCl4 Induced Lung and Thyroid Toxicity in Rat Model. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-453365
American Medical Association (AMA)
Naz, Kiran& Khan, Muhammad Rashid& Shah, Naseer Ali& Sattar, Saadia& Noureen, Farah& Awan, Madeeha Latif. Pistacia chinensis : A Potent Ameliorator of CCl4 Induced Lung and Thyroid Toxicity in Rat Model. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-453365
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453365