Differential Gene Expression Segregates Cattle Confirmed Positive for Bovine Tuberculosis from Antemortem Tuberculosis Test-False Positive Cattle Originating from Herds Free of Bovine Tuberculosis
المؤلفون المشاركون
Steibel, Juan P.
Coussens, Paul M.
Grooms, Daniel L.
Bolin, Steven R.
Lim, Ailam
المصدر
Veterinary Medicine International
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-04
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Antemortem tests for bovine tuberculosis (bTB) currently used in the US measure cell-mediated immune responses against Mycobacterium bovis.
Postmortem tests for bTB rely on observation of gross and histologic lesions of bTB, followed by bacterial isolation or molecular diagnostics.
Cumulative data from the state of Michigan indicates that 98 to 99% of cattle that react positively in antemortem tests are not confirmed positive for bTB at postmortem examination.
Understanding the fundamental differences in gene regulation between antemortem test-false positive cattle and cattle that have bTB may allow identification of molecular markers that can be exploited to better separate infected from noninfected cattle.
An immunospecific cDNA microarray was used to identify altered gene expression (P≤0.01) of 122 gene features between antemortem test-false positive cattle and bTB-infected cattle following a 4-hour stimulation of whole blood with tuberculin.
Further analysis using quantitative real-time PCR assays validated altered expression of 8 genes that had differential power (adj P≤0.05) to segregate cattle confirmed positive for bovine tuberculosis from antemortem tuberculosis test-false positive cattle originating from herds free of bovine tuberculosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lim, Ailam& Steibel, Juan P.& Coussens, Paul M.& Grooms, Daniel L.& Bolin, Steven R.. 2012. Differential Gene Expression Segregates Cattle Confirmed Positive for Bovine Tuberculosis from Antemortem Tuberculosis Test-False Positive Cattle Originating from Herds Free of Bovine Tuberculosis. Veterinary Medicine International،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-453370
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lim, Ailam…[et al.]. Differential Gene Expression Segregates Cattle Confirmed Positive for Bovine Tuberculosis from Antemortem Tuberculosis Test-False Positive Cattle Originating from Herds Free of Bovine Tuberculosis. Veterinary Medicine International No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-453370
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lim, Ailam& Steibel, Juan P.& Coussens, Paul M.& Grooms, Daniel L.& Bolin, Steven R.. Differential Gene Expression Segregates Cattle Confirmed Positive for Bovine Tuberculosis from Antemortem Tuberculosis Test-False Positive Cattle Originating from Herds Free of Bovine Tuberculosis. Veterinary Medicine International. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-453370
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-453370
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر