WY-14643, a Potent Peroxisome Proliferator Activator Receptor-α PPAR-α Agonist Ameliorates the Inflammatory Process Associated to Experimental Periodontitis

المؤلفون المشاركون

Briguglio, Francesco
Mazzon, Emanuela
Cordasco, Giancarlo
Di Paola, Rosanna
Paterniti, Irene
Cuzzocrea, Salvatore
Oteri, Giacomo

المصدر

PPAR Research

العدد

المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-13، 13ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2010-12-27

دولة النشر

مصر

عدد الصفحات

13

التخصصات الرئيسية

العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء

الملخص EN

We have investigated the effects of WY14643, a potent peroxisome proliferator activator receptor-α (PPAR-α) agonist, in a rat model of ligature-induced periodontitis.

Male Sprague-Dawley rats were lightly anaesthetized with pentobarbitone (35 mg/kg).

Sterile, 2-0 black braided silk thread was placed around the cervix of the lower left first molar and knotted medially.

Animals received WY14643 (1 mg/kg i.p, daily for eight days).

Eighths days after placement of the ligature, we evaluated several markers of inflammation such us (1) myeloperoxidase activity, (2) a cytokines and adhesion molecules expression, (3) NF-κB expression, (4) iNOS expression, (5) the nitration of tyrosine residues, (6) activation of the nuclear enzyme poly(ADP-ribose) polymerase, (7) apoptosis, and (8) the degree of gingivomucosal tissues injury.

Administration of WY14643 significantly decreased all of the parameters of inflammation as described above.

These results demonstrate that WY14643 exerts an anti-inflammatory role during experimental periodontitis and is able to ameliorate the tissue damage.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Briguglio, Francesco& Di Paola, Rosanna& Paterniti, Irene& Mazzon, Emanuela& Oteri, Giacomo& Cordasco, Giancarlo…[et al.]. 2010. WY-14643, a Potent Peroxisome Proliferator Activator Receptor-α PPAR-α Agonist Ameliorates the Inflammatory Process Associated to Experimental Periodontitis. PPAR Research،Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-453376

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Briguglio, Francesco…[et al.]. WY-14643, a Potent Peroxisome Proliferator Activator Receptor-α PPAR-α Agonist Ameliorates the Inflammatory Process Associated to Experimental Periodontitis. PPAR Research No. 2010 (2010), pp.1-13.
https://search.emarefa.net/detail/BIM-453376

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Briguglio, Francesco& Di Paola, Rosanna& Paterniti, Irene& Mazzon, Emanuela& Oteri, Giacomo& Cordasco, Giancarlo…[et al.]. WY-14643, a Potent Peroxisome Proliferator Activator Receptor-α PPAR-α Agonist Ameliorates the Inflammatory Process Associated to Experimental Periodontitis. PPAR Research. 2010. Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-453376

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-453376