WY-14643, a Potent Peroxisome Proliferator Activator Receptor-α PPAR-α Agonist Ameliorates the Inflammatory Process Associated to Experimental Periodontitis
Joint Authors
Briguglio, Francesco
Mazzon, Emanuela
Cordasco, Giancarlo
Di Paola, Rosanna
Paterniti, Irene
Cuzzocrea, Salvatore
Oteri, Giacomo
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-27
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
We have investigated the effects of WY14643, a potent peroxisome proliferator activator receptor-α (PPAR-α) agonist, in a rat model of ligature-induced periodontitis.
Male Sprague-Dawley rats were lightly anaesthetized with pentobarbitone (35 mg/kg).
Sterile, 2-0 black braided silk thread was placed around the cervix of the lower left first molar and knotted medially.
Animals received WY14643 (1 mg/kg i.p, daily for eight days).
Eighths days after placement of the ligature, we evaluated several markers of inflammation such us (1) myeloperoxidase activity, (2) a cytokines and adhesion molecules expression, (3) NF-κB expression, (4) iNOS expression, (5) the nitration of tyrosine residues, (6) activation of the nuclear enzyme poly(ADP-ribose) polymerase, (7) apoptosis, and (8) the degree of gingivomucosal tissues injury.
Administration of WY14643 significantly decreased all of the parameters of inflammation as described above.
These results demonstrate that WY14643 exerts an anti-inflammatory role during experimental periodontitis and is able to ameliorate the tissue damage.
American Psychological Association (APA)
Briguglio, Francesco& Di Paola, Rosanna& Paterniti, Irene& Mazzon, Emanuela& Oteri, Giacomo& Cordasco, Giancarlo…[et al.]. 2010. WY-14643, a Potent Peroxisome Proliferator Activator Receptor-α PPAR-α Agonist Ameliorates the Inflammatory Process Associated to Experimental Periodontitis. PPAR Research،Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-453376
Modern Language Association (MLA)
Briguglio, Francesco…[et al.]. WY-14643, a Potent Peroxisome Proliferator Activator Receptor-α PPAR-α Agonist Ameliorates the Inflammatory Process Associated to Experimental Periodontitis. PPAR Research No. 2010 (2010), pp.1-13.
https://search.emarefa.net/detail/BIM-453376
American Medical Association (AMA)
Briguglio, Francesco& Di Paola, Rosanna& Paterniti, Irene& Mazzon, Emanuela& Oteri, Giacomo& Cordasco, Giancarlo…[et al.]. WY-14643, a Potent Peroxisome Proliferator Activator Receptor-α PPAR-α Agonist Ameliorates the Inflammatory Process Associated to Experimental Periodontitis. PPAR Research. 2010. Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-453376
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453376