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Monitoring of Active Human Herpes Virus 6 Infection in Iranian Patients with Different Subtypes of Multiple Sclerosis
المؤلفون المشاركون
Niazi, Abbas Ali
Ganjali, Zohre
Moghtaderi, Ali
Sanadgol, Nima
Sarabandi, Vida
Ramrudi, Nur Allah
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-01-22
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Recently, it has been suggested that human herpes virus 6 (HHV6) may play a role in the pathogenesis of multiple sclerosis (MS).
Our purpose is to determine the incidence of reactivated HHV6 in MS patients.
Methods.
Viral sequence analyzed by qPCR in the peripheral blood mononuclear cells (PBMCs), serum, and saliva samples of different subtypes of MS patients (n=78) and healthy controls (n=123).
HHV6 IgG and IgM antibody levels measured by ELISA technique in the plasma samples of both groups.
Likewise, cerebrospinal fluid (CSF) samples of some MS patients (n=38) were analyzed for viral sequence.
Results.
Results demonstrate increased levels of anti-HHV6-IgG (78.2% versus 76.4% in controls; P=NS), and IgM (34.6% versus 6.5% in controls; P<0.05) in MS patients.
Furthermore, RRMS and SPMS patients showed relatively higher anti-HHV6 IgG and IgM compared to PPMS (P<0.001).
Moreover, load of cell-free viral DNA was higher in RRMS and SPMS patients and detected in 60.2% (47/78) of MS patients, compared with 14.6% (18/123) of healthy controls (P<0.001).
Moreover, load of cell-free viral DNA was higher in RRMS and SPMS patients and detected in 60.2% (47/78) of MS patients, compared with 14.6% (18/123) of healthy controls (P<0.001).
Conclusions.
The results extend the observation of an increased frequency of systemic reactivated HHV6 infection in MS patients with developed stages of disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ramrudi, Nur Allah& Sanadgol, Nima& Ganjali, Zohre& Niazi, Abbas Ali& Sarabandi, Vida& Moghtaderi, Ali. 2013. Monitoring of Active Human Herpes Virus 6 Infection in Iranian Patients with Different Subtypes of Multiple Sclerosis. Journal of Pathogens،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-453561
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ramrudi, Nur Allah…[et al.]. Monitoring of Active Human Herpes Virus 6 Infection in Iranian Patients with Different Subtypes of Multiple Sclerosis. Journal of Pathogens No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-453561
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ramrudi, Nur Allah& Sanadgol, Nima& Ganjali, Zohre& Niazi, Abbas Ali& Sarabandi, Vida& Moghtaderi, Ali. Monitoring of Active Human Herpes Virus 6 Infection in Iranian Patients with Different Subtypes of Multiple Sclerosis. Journal of Pathogens. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-453561
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-453561
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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