Monitoring of Active Human Herpes Virus 6 Infection in Iranian Patients with Different Subtypes of Multiple Sclerosis
Joint Authors
Niazi, Abbas Ali
Ganjali, Zohre
Moghtaderi, Ali
Sanadgol, Nima
Sarabandi, Vida
Ramrudi, Nur Allah
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Recently, it has been suggested that human herpes virus 6 (HHV6) may play a role in the pathogenesis of multiple sclerosis (MS).
Our purpose is to determine the incidence of reactivated HHV6 in MS patients.
Methods.
Viral sequence analyzed by qPCR in the peripheral blood mononuclear cells (PBMCs), serum, and saliva samples of different subtypes of MS patients (n=78) and healthy controls (n=123).
HHV6 IgG and IgM antibody levels measured by ELISA technique in the plasma samples of both groups.
Likewise, cerebrospinal fluid (CSF) samples of some MS patients (n=38) were analyzed for viral sequence.
Results.
Results demonstrate increased levels of anti-HHV6-IgG (78.2% versus 76.4% in controls; P=NS), and IgM (34.6% versus 6.5% in controls; P<0.05) in MS patients.
Furthermore, RRMS and SPMS patients showed relatively higher anti-HHV6 IgG and IgM compared to PPMS (P<0.001).
Moreover, load of cell-free viral DNA was higher in RRMS and SPMS patients and detected in 60.2% (47/78) of MS patients, compared with 14.6% (18/123) of healthy controls (P<0.001).
Moreover, load of cell-free viral DNA was higher in RRMS and SPMS patients and detected in 60.2% (47/78) of MS patients, compared with 14.6% (18/123) of healthy controls (P<0.001).
Conclusions.
The results extend the observation of an increased frequency of systemic reactivated HHV6 infection in MS patients with developed stages of disease.
American Psychological Association (APA)
Ramrudi, Nur Allah& Sanadgol, Nima& Ganjali, Zohre& Niazi, Abbas Ali& Sarabandi, Vida& Moghtaderi, Ali. 2013. Monitoring of Active Human Herpes Virus 6 Infection in Iranian Patients with Different Subtypes of Multiple Sclerosis. Journal of Pathogens،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-453561
Modern Language Association (MLA)
Ramrudi, Nur Allah…[et al.]. Monitoring of Active Human Herpes Virus 6 Infection in Iranian Patients with Different Subtypes of Multiple Sclerosis. Journal of Pathogens No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-453561
American Medical Association (AMA)
Ramrudi, Nur Allah& Sanadgol, Nima& Ganjali, Zohre& Niazi, Abbas Ali& Sarabandi, Vida& Moghtaderi, Ali. Monitoring of Active Human Herpes Virus 6 Infection in Iranian Patients with Different Subtypes of Multiple Sclerosis. Journal of Pathogens. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-453561
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453561