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Immunomodulatory Activity and Protective Effects of Polysaccharide from Eupatorium adenophorum Leaf Extract on Highly Pathogenic H5N1 Influenza Infection
المؤلفون المشاركون
Xie, Xiangming
Chang, Jianyu
Wan, Chunyan
Zhang, Yuewei
Hou, Lingyu
Fan, Kai
Wang, Hongjun
Jin, Yi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-18
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The development of novel broad-spectrum, antiviral agents against H5N1 infection is urgently needed.
In this study, we evaluated the immunomodulatory activities and protective effect of Eupatorium adenophorum polysaccharide (EAP) against the highly pathogenic H5N1 subtype influenza virus.
EAP treatment significantly increased the production of IL-6, TNF-α, and IFN-γ both in vivo and in vitro as measured by qPCR and ELISA.
In a mouse infection model, intranasal administration of EAP at a dose of 25 mg/kg body weight prior to H5N1 viral challenge efficiently inhibited viral replication, decreased lung lesions, and increased survival rate.
We further evaluated the innate immune recognition of EAP, as this process is regulated primarily Dectin-1 and mannose receptor (MR).
These results indicate that EAP may have immunomodulatory properties and a potential prophylactic effect against H5N1 influenza infection.
Our investigation suggests an alternative strategy for the development of novel antiinfluenza agents and benefits of E.
adenophorum products.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jin, Yi& Zhang, Yuewei& Wan, Chunyan& Wang, Hongjun& Hou, Lingyu& Chang, Jianyu…[et al.]. 2013. Immunomodulatory Activity and Protective Effects of Polysaccharide from Eupatorium adenophorum Leaf Extract on Highly Pathogenic H5N1 Influenza Infection. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-453564
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jin, Yi…[et al.]. Immunomodulatory Activity and Protective Effects of Polysaccharide from Eupatorium adenophorum Leaf Extract on Highly Pathogenic H5N1 Influenza Infection. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-453564
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jin, Yi& Zhang, Yuewei& Wan, Chunyan& Wang, Hongjun& Hou, Lingyu& Chang, Jianyu…[et al.]. Immunomodulatory Activity and Protective Effects of Polysaccharide from Eupatorium adenophorum Leaf Extract on Highly Pathogenic H5N1 Influenza Infection. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-453564
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-453564
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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