Immunomodulatory Activity and Protective Effects of Polysaccharide from Eupatorium adenophorum Leaf Extract on Highly Pathogenic H5N1 Influenza Infection
Joint Authors
Xie, Xiangming
Chang, Jianyu
Wan, Chunyan
Zhang, Yuewei
Hou, Lingyu
Fan, Kai
Wang, Hongjun
Jin, Yi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The development of novel broad-spectrum, antiviral agents against H5N1 infection is urgently needed.
In this study, we evaluated the immunomodulatory activities and protective effect of Eupatorium adenophorum polysaccharide (EAP) against the highly pathogenic H5N1 subtype influenza virus.
EAP treatment significantly increased the production of IL-6, TNF-α, and IFN-γ both in vivo and in vitro as measured by qPCR and ELISA.
In a mouse infection model, intranasal administration of EAP at a dose of 25 mg/kg body weight prior to H5N1 viral challenge efficiently inhibited viral replication, decreased lung lesions, and increased survival rate.
We further evaluated the innate immune recognition of EAP, as this process is regulated primarily Dectin-1 and mannose receptor (MR).
These results indicate that EAP may have immunomodulatory properties and a potential prophylactic effect against H5N1 influenza infection.
Our investigation suggests an alternative strategy for the development of novel antiinfluenza agents and benefits of E.
adenophorum products.
American Psychological Association (APA)
Jin, Yi& Zhang, Yuewei& Wan, Chunyan& Wang, Hongjun& Hou, Lingyu& Chang, Jianyu…[et al.]. 2013. Immunomodulatory Activity and Protective Effects of Polysaccharide from Eupatorium adenophorum Leaf Extract on Highly Pathogenic H5N1 Influenza Infection. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-453564
Modern Language Association (MLA)
Jin, Yi…[et al.]. Immunomodulatory Activity and Protective Effects of Polysaccharide from Eupatorium adenophorum Leaf Extract on Highly Pathogenic H5N1 Influenza Infection. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-453564
American Medical Association (AMA)
Jin, Yi& Zhang, Yuewei& Wan, Chunyan& Wang, Hongjun& Hou, Lingyu& Chang, Jianyu…[et al.]. Immunomodulatory Activity and Protective Effects of Polysaccharide from Eupatorium adenophorum Leaf Extract on Highly Pathogenic H5N1 Influenza Infection. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-453564
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453564