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Pregnancy Outcomes in HIV-Infected Women Receiving Long-Term Isoniazid Prophylaxis for Tuberculosis and Antiretroviral Therapy
المؤلفون المشاركون
Mathoma, Anikie
Mathebula, Unami
Taylor, Allan W.
Samandari, Taraz
Theebetsile, Irene
Moathlodi, Ritah
Mosimaneotsile, Barudi
المصدر
Infectious Diseases in Obstetrics and Gynecology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-07
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Objective.
While 6- to 12-month courses of isoniazid for tuberculosis prevention are considered safe in pregnant women, the effects of longer-term isoniazid prophylaxis or isoniazid in combination with antiretroviral therapy (ART) are not established in human-immunodeficiency-virus-(HIV-) infected women who experience pregnancy during the course of therapy.
Design.
Nested study of pregnancy outcomes among HIV-infected women participating in a placebo-controlled, TB-prevention trial using 36 months daily isoniazid.
Pregnancy outcomes were collected by interview and record review.
Results.
Among 196 pregnant women, 103 (52.6%) were exposed to isoniazid during pregnancy; all were exposed to antiretroviral drugs.
Prior to pregnancy they had received a median of 341 days (range 1–1095) of isoniazid.
We observed no isoniazid-associated hepatitis or other severe isoniazid-associated adverse events in the 103 women.
Pregnancy outcomes were 132 term live births, 42 premature births, 11 stillbirths, 8 low birth weight, 6 spontaneous abortions, 4 neonatal deaths, and 1 congenital abnormality.
In a multivariable model, neither isoniazid nor ART exposure during pregnancy was significantly associated with adverse pregnancy outcome (adjusted odds ratios 0.6, 95% CI: 0.3–1.1 and 1.8, 95% CI 0.9–3.6, resp.).
Conclusions.
Long-term isoniazid prophylaxis was not associated with adverse pregnancy outcomes, such as preterm delivery, even in the context of ART exposure.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Taylor, Allan W.& Mosimaneotsile, Barudi& Mathebula, Unami& Mathoma, Anikie& Moathlodi, Ritah& Theebetsile, Irene…[et al.]. 2013. Pregnancy Outcomes in HIV-Infected Women Receiving Long-Term Isoniazid Prophylaxis for Tuberculosis and Antiretroviral Therapy. Infectious Diseases in Obstetrics and Gynecology،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-453612
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Taylor, Allan W.…[et al.]. Pregnancy Outcomes in HIV-Infected Women Receiving Long-Term Isoniazid Prophylaxis for Tuberculosis and Antiretroviral Therapy. Infectious Diseases in Obstetrics and Gynecology No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-453612
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Taylor, Allan W.& Mosimaneotsile, Barudi& Mathebula, Unami& Mathoma, Anikie& Moathlodi, Ritah& Theebetsile, Irene…[et al.]. Pregnancy Outcomes in HIV-Infected Women Receiving Long-Term Isoniazid Prophylaxis for Tuberculosis and Antiretroviral Therapy. Infectious Diseases in Obstetrics and Gynecology. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-453612
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-453612
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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