Pregnancy Outcomes in HIV-Infected Women Receiving Long-Term Isoniazid Prophylaxis for Tuberculosis and Antiretroviral Therapy
Joint Authors
Mathoma, Anikie
Mathebula, Unami
Taylor, Allan W.
Samandari, Taraz
Theebetsile, Irene
Moathlodi, Ritah
Mosimaneotsile, Barudi
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-07
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
While 6- to 12-month courses of isoniazid for tuberculosis prevention are considered safe in pregnant women, the effects of longer-term isoniazid prophylaxis or isoniazid in combination with antiretroviral therapy (ART) are not established in human-immunodeficiency-virus-(HIV-) infected women who experience pregnancy during the course of therapy.
Design.
Nested study of pregnancy outcomes among HIV-infected women participating in a placebo-controlled, TB-prevention trial using 36 months daily isoniazid.
Pregnancy outcomes were collected by interview and record review.
Results.
Among 196 pregnant women, 103 (52.6%) were exposed to isoniazid during pregnancy; all were exposed to antiretroviral drugs.
Prior to pregnancy they had received a median of 341 days (range 1–1095) of isoniazid.
We observed no isoniazid-associated hepatitis or other severe isoniazid-associated adverse events in the 103 women.
Pregnancy outcomes were 132 term live births, 42 premature births, 11 stillbirths, 8 low birth weight, 6 spontaneous abortions, 4 neonatal deaths, and 1 congenital abnormality.
In a multivariable model, neither isoniazid nor ART exposure during pregnancy was significantly associated with adverse pregnancy outcome (adjusted odds ratios 0.6, 95% CI: 0.3–1.1 and 1.8, 95% CI 0.9–3.6, resp.).
Conclusions.
Long-term isoniazid prophylaxis was not associated with adverse pregnancy outcomes, such as preterm delivery, even in the context of ART exposure.
American Psychological Association (APA)
Taylor, Allan W.& Mosimaneotsile, Barudi& Mathebula, Unami& Mathoma, Anikie& Moathlodi, Ritah& Theebetsile, Irene…[et al.]. 2013. Pregnancy Outcomes in HIV-Infected Women Receiving Long-Term Isoniazid Prophylaxis for Tuberculosis and Antiretroviral Therapy. Infectious Diseases in Obstetrics and Gynecology،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-453612
Modern Language Association (MLA)
Taylor, Allan W.…[et al.]. Pregnancy Outcomes in HIV-Infected Women Receiving Long-Term Isoniazid Prophylaxis for Tuberculosis and Antiretroviral Therapy. Infectious Diseases in Obstetrics and Gynecology No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-453612
American Medical Association (AMA)
Taylor, Allan W.& Mosimaneotsile, Barudi& Mathebula, Unami& Mathoma, Anikie& Moathlodi, Ritah& Theebetsile, Irene…[et al.]. Pregnancy Outcomes in HIV-Infected Women Receiving Long-Term Isoniazid Prophylaxis for Tuberculosis and Antiretroviral Therapy. Infectious Diseases in Obstetrics and Gynecology. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-453612
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453612