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Association between Osteocalcin, Metabolic Syndrome, and Cardiovascular Risk Factors : Role of Total and Undercarboxylated Osteocalcin in Patients with Type 2 Diabetes
المؤلفون المشاركون
Masood, Afshan
Alfadda, Assim A.
Dekhil, Hafedh
Shaikh, Shaffi Ahamed
Goran, Michael I.
المصدر
International Journal of Endocrinology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-09
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Studies have demonstrated that total osteocalcin (TOC) is associated with metabolic syndrome (MetS) and therefore might influence the risk of cardiovascular disease in humans.
Undercarboxylated osteocalcin (uOC) regulates insulin secretion and sensitivity in mice, but its relation to MetS in humans is unclear.
We aimed to determine whether uOC is related to MetS and/or its individual components and other cardiovascular risk factors in patients with type 2 diabetes mellitus (T2DM), and whether TOC and uOC have utility in predicting the cardiovascular risk.
We studied 203 T2DM patients with and without MetS.
MetS was defined based on the NCEP-ATP III criteria.
A correlation analysis was performed between the three outcome variables: (i) TOC, (ii) uOC, and (iii) carboxylated osteocalcin (cOC) and MetS components and other cardiovascular risk factors.
Both TOC and uOC were significantly lower in patients with MetS compared to those without MetS, independent of body mass index.
In patients with MetS, uOC was significantly and positively correlated with HDL cholesterol, while TOC was significantly and negatively correlated with serum triglycerides.
We report for the first time that uOC is related to lipid indices in patients with T2DM.
Further studies are necessary to determine whether uOC can be utilized for cardiovascular risk assessments in these patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alfadda, Assim A.& Masood, Afshan& Shaikh, Shaffi Ahamed& Dekhil, Hafedh& Goran, Michael I.. 2013. Association between Osteocalcin, Metabolic Syndrome, and Cardiovascular Risk Factors : Role of Total and Undercarboxylated Osteocalcin in Patients with Type 2 Diabetes. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-453806
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alfadda, Assim A.…[et al.]. Association between Osteocalcin, Metabolic Syndrome, and Cardiovascular Risk Factors : Role of Total and Undercarboxylated Osteocalcin in Patients with Type 2 Diabetes. International Journal of Endocrinology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-453806
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alfadda, Assim A.& Masood, Afshan& Shaikh, Shaffi Ahamed& Dekhil, Hafedh& Goran, Michael I.. Association between Osteocalcin, Metabolic Syndrome, and Cardiovascular Risk Factors : Role of Total and Undercarboxylated Osteocalcin in Patients with Type 2 Diabetes. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-453806
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-453806
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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