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Association between Osteocalcin, Metabolic Syndrome, and Cardiovascular Risk Factors : Role of Total and Undercarboxylated Osteocalcin in Patients with Type 2 Diabetes
Joint Authors
Masood, Afshan
Alfadda, Assim A.
Dekhil, Hafedh
Shaikh, Shaffi Ahamed
Goran, Michael I.
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Studies have demonstrated that total osteocalcin (TOC) is associated with metabolic syndrome (MetS) and therefore might influence the risk of cardiovascular disease in humans.
Undercarboxylated osteocalcin (uOC) regulates insulin secretion and sensitivity in mice, but its relation to MetS in humans is unclear.
We aimed to determine whether uOC is related to MetS and/or its individual components and other cardiovascular risk factors in patients with type 2 diabetes mellitus (T2DM), and whether TOC and uOC have utility in predicting the cardiovascular risk.
We studied 203 T2DM patients with and without MetS.
MetS was defined based on the NCEP-ATP III criteria.
A correlation analysis was performed between the three outcome variables: (i) TOC, (ii) uOC, and (iii) carboxylated osteocalcin (cOC) and MetS components and other cardiovascular risk factors.
Both TOC and uOC were significantly lower in patients with MetS compared to those without MetS, independent of body mass index.
In patients with MetS, uOC was significantly and positively correlated with HDL cholesterol, while TOC was significantly and negatively correlated with serum triglycerides.
We report for the first time that uOC is related to lipid indices in patients with T2DM.
Further studies are necessary to determine whether uOC can be utilized for cardiovascular risk assessments in these patients.
American Psychological Association (APA)
Alfadda, Assim A.& Masood, Afshan& Shaikh, Shaffi Ahamed& Dekhil, Hafedh& Goran, Michael I.. 2013. Association between Osteocalcin, Metabolic Syndrome, and Cardiovascular Risk Factors : Role of Total and Undercarboxylated Osteocalcin in Patients with Type 2 Diabetes. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-453806
Modern Language Association (MLA)
Alfadda, Assim A.…[et al.]. Association between Osteocalcin, Metabolic Syndrome, and Cardiovascular Risk Factors : Role of Total and Undercarboxylated Osteocalcin in Patients with Type 2 Diabetes. International Journal of Endocrinology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-453806
American Medical Association (AMA)
Alfadda, Assim A.& Masood, Afshan& Shaikh, Shaffi Ahamed& Dekhil, Hafedh& Goran, Michael I.. Association between Osteocalcin, Metabolic Syndrome, and Cardiovascular Risk Factors : Role of Total and Undercarboxylated Osteocalcin in Patients with Type 2 Diabetes. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-453806
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453806