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Polyomavirus JC in the Context of Immunosuppression : A Series of Adaptive, DNA Replication-Driven Recombination Events in the Development of Progressive Multifocal Leukoencephalopathy
المؤلفون المشاركون
Lundberg, Patric S.
Daniel, Dianne C.
Johnson, Edward M.
Wortman, Margaret J.
Dagdanova, Ayuna V.
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-15
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Polyomavirus JC (JCV) is the etiological agent of progressive multifocal leukoencephalopathy (PML), a demyelinating infection of oligodendrocytes in the brain.
PML, a frequently fatal opportunistic infection in AIDS, has also emerged as a consequence of treatment with several new immunosuppressive therapeutic agents.
Although nearly 80% of adults are seropositive, JCV attains an ability to infect glial cells in only a minority of people.
Data suggest that JCV undergoes sequence alterations that accompany this ability, and these changes can be derived from an archetype strain by mutation, deletion, and duplication.
While the introductory source and primary tissue reservoir of JCV remain unknown, lymphoid cells have been identified as potential intermediaries in progression of JCV to the brain.
This review is focused on sequence changes in the noncoding control region (NCCR) of the virus.
We propose an adaptive mechanism that involves a sequential series of DNA replication-driven NCCR recombination events involving stalled DNA replication forks at NCCR palindromic secondary structures.
We shall describe how the NCCR sequence changes point to a model in which viral DNA replication drives NCCR recombination, allowing JCV adaptation to different cell types in its progression to neurovirulence.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Johnson, Edward M.& Wortman, Margaret J.& Dagdanova, Ayuna V.& Lundberg, Patric S.& Daniel, Dianne C.. 2013. Polyomavirus JC in the Context of Immunosuppression : A Series of Adaptive, DNA Replication-Driven Recombination Events in the Development of Progressive Multifocal Leukoencephalopathy. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-453825
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Johnson, Edward M.…[et al.]. Polyomavirus JC in the Context of Immunosuppression : A Series of Adaptive, DNA Replication-Driven Recombination Events in the Development of Progressive Multifocal Leukoencephalopathy. Clinical and Developmental Immunology No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-453825
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Johnson, Edward M.& Wortman, Margaret J.& Dagdanova, Ayuna V.& Lundberg, Patric S.& Daniel, Dianne C.. Polyomavirus JC in the Context of Immunosuppression : A Series of Adaptive, DNA Replication-Driven Recombination Events in the Development of Progressive Multifocal Leukoencephalopathy. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-453825
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-453825
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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