Polyomavirus JC in the Context of Immunosuppression : A Series of Adaptive, DNA Replication-Driven Recombination Events in the Development of Progressive Multifocal Leukoencephalopathy
Joint Authors
Lundberg, Patric S.
Daniel, Dianne C.
Johnson, Edward M.
Wortman, Margaret J.
Dagdanova, Ayuna V.
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Polyomavirus JC (JCV) is the etiological agent of progressive multifocal leukoencephalopathy (PML), a demyelinating infection of oligodendrocytes in the brain.
PML, a frequently fatal opportunistic infection in AIDS, has also emerged as a consequence of treatment with several new immunosuppressive therapeutic agents.
Although nearly 80% of adults are seropositive, JCV attains an ability to infect glial cells in only a minority of people.
Data suggest that JCV undergoes sequence alterations that accompany this ability, and these changes can be derived from an archetype strain by mutation, deletion, and duplication.
While the introductory source and primary tissue reservoir of JCV remain unknown, lymphoid cells have been identified as potential intermediaries in progression of JCV to the brain.
This review is focused on sequence changes in the noncoding control region (NCCR) of the virus.
We propose an adaptive mechanism that involves a sequential series of DNA replication-driven NCCR recombination events involving stalled DNA replication forks at NCCR palindromic secondary structures.
We shall describe how the NCCR sequence changes point to a model in which viral DNA replication drives NCCR recombination, allowing JCV adaptation to different cell types in its progression to neurovirulence.
American Psychological Association (APA)
Johnson, Edward M.& Wortman, Margaret J.& Dagdanova, Ayuna V.& Lundberg, Patric S.& Daniel, Dianne C.. 2013. Polyomavirus JC in the Context of Immunosuppression : A Series of Adaptive, DNA Replication-Driven Recombination Events in the Development of Progressive Multifocal Leukoencephalopathy. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-453825
Modern Language Association (MLA)
Johnson, Edward M.…[et al.]. Polyomavirus JC in the Context of Immunosuppression : A Series of Adaptive, DNA Replication-Driven Recombination Events in the Development of Progressive Multifocal Leukoencephalopathy. Clinical and Developmental Immunology No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-453825
American Medical Association (AMA)
Johnson, Edward M.& Wortman, Margaret J.& Dagdanova, Ayuna V.& Lundberg, Patric S.& Daniel, Dianne C.. Polyomavirus JC in the Context of Immunosuppression : A Series of Adaptive, DNA Replication-Driven Recombination Events in the Development of Progressive Multifocal Leukoencephalopathy. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-453825
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453825